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BLAD (Bovine Leukocyte Adhesion deficiency)

Test number: 8001CattleGD

BLAD

Breed
Holstein .
The Disease
Bovine Leucocyte Adhesion Deficiency is a lethal autosomal recessive disease of Holstein cattle. Affected calves suffer from frequent infections, which either fail to respond to or recur after conventional treatment. They normally die before reaching sexual maturity.
Trait of Inheritance
Bovine Leucocyte Adhesion Deficiency is an inherited autosomal recessive trait. This means that a horse can be genetically clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected horses is the key to controlling this disease.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cattle is noncarrier of the mutant gene.

It is very unlikely that the cattle will develop BLAD (Bovine Leukocyte Adhesion deficiency). The cattle will never pass the mutation to its offspring, and therefore it can be bred to any other cattle.

 

Carrier

Genotype: N / BLAD [ Heterozygous ]

The cattle carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cattle will develop BLAD (Bovine Leukocyte Adhesion deficiency) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cattles.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: BLAD / BLAD [ Homozygous mutant ]

 

The cattle carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cattle is likely to develop BLAD (Bovine Leukocyte Adhesion deficiency) and will pass the mutant gene to its entire offspring
Description

This is a mutation-based gene test, which offers many advantages over other methods

The genetic defect leading to the disease has been identified. By DNA testing the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear horses, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.

Sample Requirements
Buccal Swabs. Buccal swabs. .
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
A2 ( Beta Casein ) Genotyping  
Freemartinism *  

 
 
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LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066