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PSSM (Polysaccharid Storage Myopathy)

Test number: 8138HGD

P

Breeds
All Horse Breeds , American Paint Horse , Appaloosas , Draft Breeds , Quarter Horse (Horse with quarter horse blood) , Warmblood .
The Disease
PSSM is a debilitating up to even life-threatening glycogen storage myopathy which is highly prevalent in multiple breeds of horses. Primarily affected are QHs, American Paint Horses, Appaloosas, but also Draft Horses and Warmbloods and crossbreeds of all of them. The hallmark of PSSM is the accumulation of abnormal polysaccharides within the muscles as well as the abnormal accumulation of glycogen.
Clinical Signs
PSSM-horses show signs typically associated with tying-up: reluctance to move, muscle-tremor, muscle stiffness, sweating, shifting lameness, stretching of the hindlegs and inability to move. Episodes usually begin after 10 to 20 minutes of light exercise. Muscles of the most affected hind quarters are firm and hard or even painful. Many of the horses have an anamnesis of repeated episodes of muscular problems. With severe symptoms the disease can result in a myoglobinuria and possibly renal problems. All together, PSSM is thought to be responsible for a large portion of neuromuscular diseases in affected breeds
Trait of Inheritance
A horse inherits one copy of the gene from each parent, a normal gene is abbreviated as N while a mutant gene is abbreviated as P. in dominant inheritance, if one of the genes is mutant (P/N) the horse is expected to be affected by the PSSM. If the two inherited genes are mutant (P/P) the horse is homozygous and is expected to show severe signs of the disease.

Inheritance : AUTOSOMAL DOMINANT trait
Description

The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear horses. This is an essential information for controlling the disease.

Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. Hair sample from mane with roots (approx 30 hairs) , Buccal swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. .
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
HYPP (Hypercalaemic Periodic Paralysis)  
IMM and MYH1 Myopathy ( MYHM )  
OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo)  
H-JEB (Herlitz Junctional epidermolysis bullosa)  
HERDA (Hereditary Equine Regional Dermal Asthenia)  
Cerebellar Abiotrophy (CA)  
Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)  
Glycogen Branching Enzyme Deficiency (GBED)  
Equine Malignant Hypethermia (EMH)  
Warmblood Fragile Foal Syndrome (WFFS)  
Hereditary Myotonia / Congenital Myotonia  
Special Offer 1: PSSM + HERDA + GBED + HYPP (Save £54)  
Special Offer 2: PSSM + HERDA + GBED + HYPP + OLWS (Save £90.00)  
Special Offer 3: CA + LFS + SCID (Save £12)  
Connemara Pony Hoof Wall Separation Disease  
5 Panel test: PSSM + HERDA + GBED + HYPP + EMH (Save £90.00)  
FOAL IMMUNODEFICIENCY SYNDROME (FIS)  
Special Offer Quarab: PSSM + HERDA + GBED + CA + SCID  
Naked Foal Syndrome ( NFS )  
Ocular Squamous Cell Carcinoma (SCC)  
SCID (Severe Combined Immunodeficiency)  

 
 
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LABOKLIN GmbH & Co. KG
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© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066