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Cerebellar Abiotrophy (CA)

Test number: 8200HGD

CA

Breeds
Arabian , Quarab .
The Disease
Cerebellar Abiotrophy (CA) is a genetic neurological disease that affects Arabian horses, it is characterised by lack of balance (Ataxia) and coordination, head tremors, stiff or high stepping gait, hyperreactivity, inability to determine space and distance in addition to other neurological symptoms. The disease develops when the neuron cells in the in the Cerebellum start to die.
Clinical Signs
Most affected foals appear normal at birth, symptoms start to become noticeable at an average age of four months but may appear as early 6 weeks of age or ever earlier. Symptoms include lack of balance (Ataxia), head tremor (intention tremor), hyperreativity, stiff or high stepping gait, wide based stance, apparent lack of awareness of where the feet are (sometimes standing or trying to walk with a foot knuckled over), poor depth perception, and a general inability to determine space and distance. The disease vary in severity, mildly affected horses may live normal life span, others may experience difficulty stepping up and over objects, run into fences, fall easily and injure themselves, sometimes these horses are euthanized.
Trait of Inheritance
Cerebellar Abiotrophy (CA) has a recessive trait of inheritance which means that only horses that carry two copies of the mutation (CA/CA) will be affected by the mutation, carrier horses (N/ CA) will not develop the disease but may pass it on to their offspring, therefore genetic testing is important to control the spread of the disease.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.

It is very unlikely that the horse will develop Cerebellar Abiotrophy (CA). The horse will never pass the mutation to its offspring, and therefore it can be bred to any other horse.

 

Carrier

Genotype: N / CA [ Heterozygous ]

The horse carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the horse will develop Cerebellar Abiotrophy (CA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear horses.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: CA / CA [ Homozygous mutant ]

 

The horse carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The horse is likely to develop Cerebellar Abiotrophy (CA) and will pass the mutant gene to its entire offspring
Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.

Hair sample from mane with roots (approx 30 hairs) , Buccal swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.

.
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
HYPP (Hypercalaemic Periodic Paralysis)  
IMM and MYH1 Myopathy ( MYHM )  
OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo)  
H-JEB (Herlitz Junctional epidermolysis bullosa)  
HERDA (Hereditary Equine Regional Dermal Asthenia)  
PSSM (Polysaccharid Storage Myopathy)  
Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)  
Glycogen Branching Enzyme Deficiency (GBED)  
Equine Malignant Hypethermia (EMH)  
Warmblood Fragile Foal Syndrome (WFFS)  
Hereditary Myotonia / Congenital Myotonia  
Special Offer 1: PSSM + HERDA + GBED + HYPP (Save £54)  
Special Offer 2: PSSM + HERDA + GBED + HYPP + OLWS (Save £90.00)  
Special Offer 3: CA + LFS + SCID (Save £12)  
Connemara Pony Hoof Wall Separation Disease  
5 Panel test: PSSM + HERDA + GBED + HYPP + EMH (Save £90.00)  
FOAL IMMUNODEFICIENCY SYNDROME (FIS)  
Special Offer Quarab: PSSM + HERDA + GBED + CA + SCID  
Naked Foal Syndrome ( NFS )  
Ocular Squamous Cell Carcinoma (SCC)  
SCID (Severe Combined Immunodeficiency)  

 
 
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125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066