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Ocular Squamous Cell Carcinoma (SCC)

Test number: 8292

R

Breeds
Belgian Horses , Haflinger .
The Disease
Genetic risk factor for equine eye cancer found

This test is for the marker that is associated with higher risk of of developing limbal squamous cell carcinoma (SCC) in Haflinger and Belgian horses. The markerwas identified by researchers at UC Davis School of Veterinary Medicine and the Veterinary Genetics Laboratory investigating ocular Squamous Cell Carcinoma (SCC). This cancer occurs on the limbus, which is the junction of the cornea and the sclera), and/or third eye lid. When occuring at the limbus, SCC can spread into the cornea leading to visual impairment and destruction of the eye. Horses which are tested homozygous (R/R) for the risk factor are 5.6 times (Haflinger) or 4.0 times (Belgians) more likely to develop ocular SCC than those with one copy (R/N) or no copies (N/N) of the risk factor. This risk factor does not explain all cases of ocular SCC but it appears to be a major contributor in Haflingers and Belgians.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.

No copies of the SCC-associated marker. Horse has a lower risk of developing limbal or third eye lid SCC.

 

Carrier

Genotype: N / R [ Heterozygous ]

The horse carries one copy of the mutant gene and one copy of the normal gene.

1 copy of the SCC-associated marker. Horse has a lower risk of developing ocular SCC but can pass on the risk factor to 50% of the offspring.

 

Affected

Genotype: R / R [ Homozygous mutant ]

 

The horse carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

2 copies of the SCC-associated risk marker. Horse is 4.0 (Belgian) or 5.6 (Haflinger) times more likely to develop SCC in its lifetime when compared to N/R and N/N. Routine ophthalmological exams and use of UV-protecting fly masks during sun exposure are advised.
Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. Hair sample from mane with roots (approx 30 hairs) , Buccal swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. .
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
HYPP (Hypercalaemic Periodic Paralysis)  
IMM and MYH1 Myopathy ( MYHM )  
OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo)  
H-JEB (Herlitz Junctional epidermolysis bullosa)  
HERDA (Hereditary Equine Regional Dermal Asthenia)  
PSSM (Polysaccharid Storage Myopathy)  
Cerebellar Abiotrophy (CA)  
Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)  
Glycogen Branching Enzyme Deficiency (GBED)  
Equine Malignant Hypethermia (EMH)  
Warmblood Fragile Foal Syndrome (WFFS)  
Hereditary Myotonia / Congenital Myotonia  
Special Offer 1: PSSM + HERDA + GBED + HYPP (Save £54)  
Special Offer 2: PSSM + HERDA + GBED + HYPP + OLWS (Save £90.00)  
Special Offer 3: CA + LFS + SCID (Save £12)  
Connemara Pony Hoof Wall Separation Disease  
5 Panel test: PSSM + HERDA + GBED + HYPP + EMH (Save £90.00)  
FOAL IMMUNODEFICIENCY SYNDROME (FIS)  
Special Offer Quarab: PSSM + HERDA + GBED + CA + SCID  
Naked Foal Syndrome ( NFS )  
SCID (Severe Combined Immunodeficiency)  

 
 
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LABOKLIN GmbH & Co. KG
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© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066