We are pleased to announce that LABOKLIN will
be at the GCCF Supreme Cat Show on Saturday 18th
October 2025 and we look forward to seeing you there.
Meet the experts
We are pleased to announce that our feline genetics
expert Nadine Gaenstaller will be at the show and
will be very pleased to answer any questions or
queries you have.
We always talk on the phone, by email or even
via facebook, however, at the GCCF we are very excited
to meet you in person and to answer any questions
you have, please stop by and say hi.
The Show offer
10% discount on all
DNA tests submitted at the GCCF Supreme Cat Show!
and this offer includes our Breed Specific DNA Bundles
which are already heavily discounted.
How to submit a sample at the GCCF show:
Bring your cat to our stand: we will take
a DNA sample for your genetic test, all you
need to do is complete the order form and pay
the fees. Or,
If you don't want to wait in the queue,
or if you are attending the show without your
cats, you can prepare your sample in advance
and bring it together with the attached order
form with you to our stand. You can order a
free DNA testing kit on our website, click on
the following link to order:
We will send you a testing kit which also
contains
order form and instructions on how to take
DNA sample from the mouth. Prepare your sample
up to a week before your planned visit, just
hand the sample to us at the show.
If you prefer to use blood for your test,
ask your vet to collect 0.5-1 ml of whole blood
in EDTA blood tube, bring it together with the
completed order form (click
here to download the show discounted form)
to the show, just hand it to us. (you can order
free EDTA blood tube from our website http://www.laboklin.co.uk
)
Payments can be made by card, cheque, cash, postal
Order, bank transfer and paypal.
Turnaround: 1-3 weeks for the majority of tests
from Monday 20TH October
The attached order form will only be accepted
at the GCCF Supreme Cat Show 2025.
If you have any questions, please email info@laboklin.co.uk
or ring 0161 2823066.
We look forward to seeing you
Kind regards
The Laboklin Team
LABOKLIN (UK)
Laboratory For Veterinary Diagnostics Unit 20
Wheel Forge Way Trafford Park Manchester
M17 1EH
We are excited to introduce a DNA test for
Atherosclerosis in cats
About the Condition
Atherosclerosis is a chronic inflammatory
vascular disease caused by the accumulation
of Low Density Lipoprotein LDL-derived cholesterol
on arterial walls. While this condition is common
in humans, it is rare in animals. Recent research
has identified spontaneous cases of atherosclerosis
in Korat cats, marked by severe hypercholesterolemia
and clinical signs of congestive heart failure.
These findings revealed histopathological similarities
to human atherosclerosis.
Why Test?
Our DNA test targets this specific genetic
variant, providing valuable insights for breeders,
veterinarians, and researchers. Early identification
of this mutation can help manage the health
of affected cats and guide breeding decisions
to reduce its prevalence.
in Nova Scotia Duck Tolling
Retrive (NSDTR /Toller)
Degenerative Encephalopathy (DE)
In the Nova Scotia Duck Tolling Retriever
(NSDTR) breed, a slowly progressive
hereditary neurological disorder known as
Degenerative Encephalopathy (DE)
has been identified. Affected dogs typically
exhibit frequent episodes of pronounced
involuntary movements during sleep,
along with:
Cognitive impairment
Anxiety
Increased sensitivity to sensory stimuli
Compulsive behaviours
As the disease progresses, degeneration occurs
in multiple brain regions. In later stages,
some dogs may also develop:
Aggressive behaviour
Gait abnormalities
Urinary or fecal incontinence
The onset of clinical signs
has been reported to vary between 2
months and 5 years of age, with
severity increasing over time.
A genetic variant in the RB1CC1 gene
has been identified as a risk factor for DE
in NSDTRs. The RB1CC1 protein
plays a central role in macroautophagy?a
cellular process in which damaged intracellular
components are enclosed in membrane-bound organelles
(autophagosomes), which then fuse with lysosomes
to degrade their contents and maintain cellular
homeostasis. Consistent with this mechanism,
neurons in the brain of an affected dog were
found to contain abnormal lysosomal
storage body-like inclusions.
The genetic test enables
breeders to identify carriers of the
risk variant, helping to prevent affected
offspring through informed breeding decisions.
It can also support clinical diagnosis
in dogs presenting with relevant neurological
symptoms.
In the Bengal cat breed, a genetic variant
of the CAD gene has been found to be
associated with epileptic encephalopathy. An
affected Bengal kitten was reported to show
clusters of generalised tonic seizures and abnormal
behaviour as early as three months
after birth.
The seizures occurred during sleep and were
characterised by sudden jumps,
followed by opisthotonus associated
with increased muscle tone of the thoracic limbs,
head swaying, lip smacking,
chewing movements,
facial twitches, salivation,
and impaired consciousness.
These seizures lasted a few seconds to a minute,
and afterwards, the cat appeared disorientated.
The kitten was generally quieter compared
to other kittens of the same age and displayed
episodes of abnormal behaviour,
including obtundation or agitation accompanied
by biting the floor or its own paws.
Examination revealed abnormal mentation
and a bilaterally absent menace response,
as well as increased red cell distribution
width (RDW), indicating mild
anisocytosis.
The CAD gene codes for a protein
essential for the synthesis of pyrimidine nucleotides
and nucleic acids, and plays an important role
in protein glycosylation, lipid metabolism,
polysaccharide biosynthesis, and signal transduction.
As the cat showed only a partial response to
anti-epileptic drugs, the owners decided on
euthanasia due to its poor quality of life.
A genetic form of polioencephalopathy has been identified in Eurasier dogs, linked to a variant in the MECR gene. Affected puppies typically begin showing signs between 2 and 6 months of age. These include movement episodes such as wobbly walking (ataxia), exaggerated leg movements (hypermetric gait), muscle spasms (dystonia), and sudden flexing or stretching of the front legs. These episodes often become more frequent and severe over time, and may be triggered by excitement, loud noises, or overstimulation. No changes in behaviour or awareness have been reported.
Common symptoms observed in affected Eurasier puppies include:
Generalized ataxia (wobbly walking)
Hypermetric gait (exaggerated limb movements)
Dystonia (muscle spasms)
Uncontrolled flexion and extension of the forelimbs
Progressive difficulty walking and standing
Muscle atrophy
Abnormal posture
Divergent strabismus (eyes pointing outward)
Polioencephalopathy is a neurological disorder involving changes in the brain?s grey matter. It can be caused by metabolic issues and is difficult to diagnose based on symptoms alone, as signs can vary widely.
The MECR gene encodes an enzyme essential for mitochondrial energy metabolism. Variants in this gene can lead to neurodegenerative changes, especially in energy-demanding tissues such as the basal ganglia and the optic nerve.
This DNA test helps identify carriers and affected dogs early, allowing breeders to make informed decisions and reduce the risk of producing affected puppies.
Dermoid Sinus is a serious congenital condition primarily seen in Rhodesian Ridgebacks, although it can occasionally affect other breeds. It is a tubular defect that arises during embryonic development when the skin and nervous system fail to completely separate. This results in 'noodle-like' tissue formations that abnormally connect the upper layers of the skin to deeper structures, such as muscles or even the spinal cord.
Detecting Dermoid Sinus can be particularly challenging, even for experienced veterinarians, as the condition is not always visible externally and may require careful examination or imaging to identify. If left untreated, the sinus can lead to complications such as infections, abscesses, and pain, significantly affecting the dog?s health and quality of life.
Dogs affected by Dermoid Sinus, including those that have undergone surgical removal of the condition, have traditionally been excluded from breeding programs to prevent passing the condition on to their offspring, as it is highly heritable. However, with the introduction of a new DNA test for Dermoid Sinus, breeders now have the ability to make informed breeding decisions by ensuring that new born puppies are not at high risk of developing Dermoid Sinus.
Canine progressive retinal atrophies (PRA) are a group of genetically diverse diseases that cause retinal degeneration and varying degrees of vision loss. While some PRA mutations are shared across multiple breeds, many are breed-specific or found in breeds with shared ancestry.
Typical signs found by ophthalmoscopic examination are widespread tapetal hyper-reflectivity and retinal vascular attenuation.
Genetic testing complements clinical eye examinations with the advantage of detecting known PRA mutations before breeding age or before clinical signs present.
A genetic variant in the GTPBP2 gene has been associated with progressive retinal atrophy (PRA) in Labrador Retrievers. In affected animals, this variant leads to retinal degeneration, resulting in a progressive loss of vision.
The dogs exhibit typical signs of visual impairment, such as a reduced response to visual stimuli - for example, they may no longer follow a thrown ball - as well as an increased reliance on their sense of smell to navigate their surroundings.
The age of onset of the first symptoms varies and typically ranges between 7 months and 1.5 years. As the disease progresses, a secondary cataract (lens opacity) may also develop
our most comprehensive feline
genetic bundle at discounted price
very popular: our Feline XXL DNA bundle is a
large collection of genetic tests designed to unlock
the secrets of your cat's health and other traits.
This extraordinary bundle combines a diverse range
of tests carefully selected to reveal fascinating
insights about your cat�s genetic makeup and genetic
predispositions. And the best part? It will be available
at a great price.
The new, comprehensive LABOGenetics XXL Cat package
examines over 50 genetic variants
. You will receive information about hereditary
diseases, genetic risk factors, coat colors and
coat characteristics. And of course your animal's
genetic blood group shouldn't is of course also
included - for cats of all breeds and mixes!
This new package is of interest to everyone,
whether you keep cats, breed them or are a vet.
For breeders: Make informed
breeding decisions, improve the genetic health
of your breed and breed healthier offspring.
For cat owners: Gain insights
into your cat's genetics and uncover possible
health risks.
For vets: Improve your
diagnosis and treatment plans with valuable
genetic information, enabling better care for
your cat patients.
For breeding clubs: Provide
your club members with advanced genetic testing
and support responsible breeding practices.
our most comprehensive Canine
genetic bundle at discounted price
Discover Your Dog's Genetic Makeup with the New
Labogenetics Dog XXL Bundle
Unveil the secrets of your dog's DNA with the comprehensive LABOGenetics XXL Dog package, which analyzes over
340 genetic variants to provide you with detailed insights into your dog's health, characteristics,
and genetic makeup. This all-inclusive test is perfect for both purebred dogs and mixed breeds.
What You Will Receive:
Hereditary Diseases: Identify genetic health risks that could affect your dog.
Genetic Risk Factors: Understand potential health threats and take preventive measures.
Coat Colors and Characteristics: Discover the genetic factors behind your dog's unique
appearance.
Who Can Benefit?
Breeders: Make informed breeding decisions to enhance the genetic health of your breed and
ensure healthier puppies.
Dog Owners: Gain a deeper understanding of your dog's genetics to uncover potential health
risks and ensure their well-being.
Veterinarians: Enhance your diagnostic and treatment plans with valuable genetic data for
better patient care.
Breeding Clubs: Equip your members with advanced genetic testing to support responsible and
informed breeding practices.
The LABOGenetics XXL Dog package is designed to cater to everyone?from dog enthusiasts and breeders to veterinarians
and breeding clubs?providing unparalleled genetic insights to help you care for your canine companions better.
Our Canine XXL DNA bundle is a large collection of genetic tests designed to unlock the secrets of your dog?s health and other traits. This extraordinary bundle combines
a diverse range of tests carefully selected to reveal fascinating insights about your dog?s genetic makeup and genetic predispositions.
And the best part? It is available at a great price.
The LABOGenetics XXL Dog is performed using the new Next Generation Sequencing (NGS) technology.
LABOGenetics XXL Dog provides you with extensive information on genetic diseases and risk factors as well as on coat colours and traits.
GSD Breed Council DNA Profiling & Parentage Verification
We arere pleased to announce a new partnership between Laboklin, the German Shepherd Dog Breed Council (GSDBC), and the German Shepherd Dog League of Great Britain (GSDL). Together, we now offer a Premium DNA Profiling and Parentage Verification service tailored specifically for German Shepherd breeders and owners.
This service ensures accurate parentage records are maintained in a dedicated database managed by Laboklin on behalf of the GSDBC and GSDL. By leveraging advanced genetic analysis, it supports responsible breeding and contributes to the long-term health and integrity of the breed.
in Eurasier and Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
The PCD test is now validated for the following breeds: Alaskan Malamute , Australian Shepherd , Bobtail , Eurasier , Miniature American Shepherd , Nova Scotia Duck tolling Retriever ( NSDTR / Toller) , Old English Sheepdog (Bobtail) .
Note: Since different variants are found in different breeds, please note that we will only perform the variant that is relevant to the breed of the tested dog. For example, if the breed is Old English Sheepdog, we will only test for the PCD variant in the CCDC39 gene.
Primary Ciliary Dyskinesia (PCD) belongs to a genetically heterogeneous group of inherited ciliopathies. It causes impaired movement of motile cilia?microscopic hair-like structures lining the respiratory tract and other organs. When these cilia fail to function properly, mucus clearance becomes ineffective, leading to chronic inflammation and infection, particularly in the respiratory system.
LPPN3 has now been validated for Great
Dane.The test is now valid for the following
breeds: Great Dane, Labrador Retriever, Leonberger and St. Bernard. Affected puppies usually develop severe symptoms of laryngeal paralysis at young age including breathing difficulty which is often loud and gagging, difficulty in swallowing food, hanges in barking frequency and quality, high-stepping and uncoordinated gait, stumbling and tripping, exercise intolerance, and muscle atrophy.
Symptoms and Impact
Affected Leonberger puppies often develop severe symptoms at an early age, including:
Breathing difficulties, often accompanied by loud, gagging sounds
Trouble swallowing food
Changes in barking, such as hoarseness or altered frequency
Uncoordinated gait, high-stepping movement, stumbling, and tripping
Muscle atrophy and exercise intolerance
These symptoms are caused by degeneration and atrophy of the muscles that control laryngeal function, leading to impaired airflow in and out of the trachea. This results in noisy breathing, wheezing, and a characteristic roaring sound (stridor) in affected dogs.
DLA Typing - assessment of Autoimmune Risks (eg: Diabetes Millitus, Hypothyroidism, Addison's disease)
Overview
DLA genes encode proteins that play a central role in a dog?s immune response by presenting antigens on cell surfaces, enabling the immune system to distinguish between self and foreign structures. As part of the Major Histocompatibility Complex (MHC), these genes are inherited in fixed combinations called haplotypes. A high level of genetic diversity among DLA genes enhances immune responsiveness and resilience.
DLA Genes and Their Significance in Dog Breeding
What Are DLA Genes?
DLA genes belong to the MHC class II complex, which helps the immune system recognize and respond to foreign substances such as bacteria and viruses. Proper function is essential for distinguishing the body?s own cells from invaders?errors in this process can lead to autoimmune diseases.
In dogs, the MHC complex is located on chromosome 12, and the class II region is particularly important for regulating the humoral (antibody-mediated) immune response.
The three most relevant DLA genes in dog breeding are:
DLA-DRB1
DLA-DQA1
DLA-DQB1
These genes are inherited together as a haplotype, meaning a fixed combination passed from parent to offspring.
Why Are DLA Genes Important?
A high diversity of DLA genes contributes to a stable and responsive immune system. The greater the genetic diversity, the better the dog?s ability to respond to a wide range of pathogens.
However, in many breeds, selective breeding has reduced this diversity. Factors such as limited breeding pools, popular sires, and repeated mating of related dogs have narrowed the range of available haplotypes.
Breeding goal: Maintain or increase DLA diversity within the breed.
Homozygosity vs. Heterozygosity
Homozygous: Two identical alleles of a gene
Heterozygous: Two different alleles of a gene
Heterozygous dogs have greater genetic diversity in the MHC complex, which is generally beneficial for immune function.
Association with Diseases
Certain DLA haplotypes have been linked to increased or decreased risk of autoimmune diseases such as:
Diabetes mellitus
Exocrine pancreatic insufficiency
Hypothyroidism
Addison?s disease
Important notes:
The results indicate risk, not certainty.
Environmental and other genetic factors also influence disease development.
in English Springer Spaniel and Welsh Springer Spaniel .
In English Springer Spaniels (ESS) and Welsh Springer Spaniels (WSS), a genetic variant in the SERPINE1 gene has been linked to a bleeding tendency caused by hyperfibrinolysis.
Hyperfibrinolysis is a disorder in which blood clots dissolve too quickly, preventing proper wound sealing. Normally, fibrinolysis breaks down clots gradually after healing. In affected dogs, this process occurs prematurely and excessively, leading to persistent or delayed bleeding.
Clinical signs often appear from around 7 months of age, typically following surgery or trauma. Affected dogs may experience spontaneous bleeding into the abdominal cavity or subcutaneous tissue, hematomas, or bloody wound secretions. They may appear weak and lethargic, with pale gums and a low pulse.
It is important to note that this is a disorder of clot stability, not clot formation. Bleeding typically begins within 24?48 hours after surgery or trauma due to the absence of functional PAI-1 protein, which normally inhibits premature clot breakdown.
more breeds are now covered
by our popular DNA bundles
We continue to expand our range of breed specific
DNA bundles for cats to cover more breeds. Each
bundle includes the most relevant DNA tests for
the breed at a discounted price.
Red Coat Colour Test for Cats (Orange / Tortoiseshell / Calico)
The distinctive red coat colour in cats is determined by a genetic variant of the Arhgap36 gene, located on the X chromosome. This variant is inherited in a sex-linked manner and affects pigmentation by suppressing the black-brown pigment eumelanin and enhancing the orange pigment pheomelanin.
Male Cats: As males have only one X chromosome, they will display a red coat if they inherit the red variant (X(O)/Y). Without this variant (X(o)/Y), they will not have a red coat.
Female Cats: Females possess two X chromosomes and require two copies of the red variant (X(O)/X(O)) for their coat to be completely red. If only one X chromosome carries the red variant (X(O)/X(o)), random X chromosome inactivation results in a combination of red and non-red areas, producing the beautiful tortoiseshell or calico patterns. Cats with the genotype (X(o)/X(o)) will not display the red coat colour.
This test provides valuable insights into the inheritance of red coat colour, assisting breeders in understanding and predicting coat patterns in their litters.
The Sunshine gene is a coat colour modifier described in Siberian cats that creates a warm, golden apricot-toned tabby appearance instead of the typical darker tabby markings.
The following tests are now part of the Kennel Club DNA testing schemes:
Degenerative Myelopathy DM Exon 2 in Rhodesian Ridgeback
more ..
Hyperuricosuria / Urate Stones (HUU, SLC) in Giant Schnauzer more ..
Progressive Retinal Atrophy (prcd-PRA) in Russian Black Terrier more ..
Dilated Cardiomyopathy (JDCM) in Manchester Terrier and English Toy Terrier more ..
Xanthinuria Type II in Manchester Terrier and English Toy Terrier more ..
testing is easy
To test an animal, we need a DNA sample, which
can be collected using simple mouth swabs or a blood
sample collected by the vet. Both buccal swabs and
blood tubes are available from us free of charge.
Samples can be sent to our Manchester address below.
LABOKLIN is a DIN EN ISO / IEC 17025 Accredited
laboratory. This means that all our tests are performed
according to the reliable accreditation standards
and verified procedures.
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LABOKLIN (UK), Unit 20, Wheel FOrge Way, Trafford Park,
Manchester M17 1EH, United Kingdom
In dogs, the MHC complex is located on chromosome 12, and the class II region is particularly important for regulating the humoral (antibody-mediated) immune response.
