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Chronic kidney disease and early detection in the creatinine blind zone are still big issues in small animal practice. The protein-creatinine ratio indicates the increased excretion of protein before creatinine retention. A new parameter, SDMA (symmetric dimethylarginine), originates from degradation of muscle cells is released from the body exclusively via the kidneys. SDMA is supposed to detect the early stages of renal dysfunction reliably and with low interference. Newer publications reported a significant inverse correlation between the glomerular filtration rate and SDMA in cats. SDMA test is recommended for detecting renal dysfunction at an early stage.
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