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Acral Mutilation Syndrome ( AMS )
Test number: 8038
Gene: AMS
Price: £ 48.00 (including VAT)
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Breeds
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Cockapoo (English)
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English Cocker Spaniel
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English Pointer
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English Springer Spaniel
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French Spaniel
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German Shorthair Pointer
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Sprocker Spaniel
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in English Cocker Spaniel, and English Springer Spaniel.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Acral Mutilation Syndrome (AMS) is an inherited sensory neuropathy disorder affecting several sporting breeds. The disease is characterised by insensitivity to pain in the feet ( acral analgesia ) which can be associated with sudden and intense licking, biting and severe self-mutilation of the feet, while proprioception, motor abilities and spinal reflexes remain intact.
Affected puppies look smaller than their healthy littermates.
Symptoms maybe followed by further complications such as infections, ulceration, nail loss, swollen paws and fractures.
Age of onset: 3-12 months |
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Trait of Inheritance |
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Recessive trait of inheritance, which means that a dog must inherit two copies of the mutation (one from each parent) to become genetically affected.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Acral Mutilation Syndrome ( AMS ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / AMS [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Acral Mutilation Syndrome ( AMS ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: AMS / AMS [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Acral Mutilation Syndrome ( AMS ) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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