|
|
|
OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo)
Test number: 8061 (this test number replaces the old 8061HGD)
Gene: LWO
Price: £ 48.00 (including VAT)
|
|
|
|
|
|
Breeds
|
|
Appaloosas
,
Paint Horse
,
Quarter Horse (Horse with quarter horse blood)
.
|
|
|
|
The Disease |
|
Lethal White Foal Syndrome is a disease associated with breeds that register white coat spotting patterns. Breedings between particular spotted horses (frame overos) produce some foals that, in contrast to their parents, are all white and die shortly after birth of severe intestinal blockage.
In addition to that, horses were identified that were carriers of the defect gene but had no recognized overo coat pattern phenotype. Apart from frame overos the test for the mutant allele is recommendable for the breeds Paint Horse, Pinto Horse and Quarter Horse.
|
|
|
|
|
Description |
|
This is a mutation-based gene test, which offers many advantages over other methods
The genetic defect leading to the disease has been identified. By DNA testing the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear horses, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
|
|
|
|
|
Trait of Inheritance |
|
The Disease
Lethal White Foal Syndrome is a disease associated with breeds that register white coat spotting patterns. Breedings between particular spotted horses (frame overos) produce some foals that, in contrast to their parents, are all white and die shortly after birth of severe intestinal blockage.
In addition to that, horses were identified that were carriers of the defect gene but had no recognized overo coat pattern phenotype. Apart from frame overos the test for the mutant allele is recommendable for the breeds Paint Horse, Pinto Horse and Quarter Horse.
The Trait of Inheritance
Lethal White Foal Syndrome is an inherited autosomal recessive trait. This means that a horse can be genetically clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected horses is the key to controlling this disease.
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
| |
|
|
|
|
|
clear
|
 |
clear
|
 |
100% clear
|
| |
|
|
|
|
|
clear
|
|
carrier
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
clear
|
|
affected
|
|
100% carriers
|
| |
|
|
|
|
|
carrier
|
|
clear
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
carrier
|
|
carrier
|
|
25% clear + 25% affected
+ 50% carriers
|
| |
|
|
|
|
|
carrier
|
|
affected
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
clear
|
|
100% carriers
|
| |
|
|
|
|
|
affected
|
|
carrier
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
affected
|
|
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The horse is noncarrier of the mutant gene.
It is very unlikely that the horse will develop OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo). The horse will never pass the mutation to its offspring, and therefore it can be bred to any other horse.
Carrier
Genotype: N / LWO [ Heterozygous ]
The horse carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the horse will develop OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear horses. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LWO / LWO [ Homozygous mutant ]
The horse carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The horse is likely to develop OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo) and will pass the mutant gene to its entire offspring
|
|
|
|
Sample Requirements |
Hair Sample from mane with roots (approx 30 hairs) or 1 ml whole blood in EDTA tube.
How to obtain a viable hair sample
Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.
|
|
|
| |
|
Price
|
|
£ 48.00 (including VAT)
|
|
|
 |
|
|
|
|
| See also: |
|
|
|
