LABOKLIN (UK)| Genetic Diseases | Dogs| Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT)
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Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT)

Test number: 8077
Gene: GT
Price: £ 48.00 (including VAT)
Breed
Pyrenean Mountain Dog (Great Pyrenees) .
The Disease
Glanzmann's thrombasthenia in Great Pyrenees is an autosomal inherited bleeding disorder. Symptoms in affected dogs starts between 3 and 6 months of age and include Affected dogs bleeding in the gum as the permanent teeth erupting. Symptoms also include nosebleeds until about 2 years of age. Skin bruising is also seen and prolonged bleeding following surgery injury and trauma, and when the female is in heat.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / GT [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: GT / GT [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT) and will pass the mutant gene to its entire offspring
 
Further reading
Glanzmann's thrombasthenia in a Great Pyrenees dogHTML file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

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