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von Willebrand disease Type I (vWD I)
Test number: 8119 (this test number replaces the old 80141)
Gene: vWDI
Price: £ 48.00 (including VAT)
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Breeds
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Barbet (French Water Dog)
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Bernese Mountain Dog
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Cavapoo
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Cockapoo (English)
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Cockapoo (American)
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Coton de Tulear
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Doberman Pinscher
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Drentsche Patrijschond
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English Toy Terrier
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German Pinscher
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Goldendoodle
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Irish Red and White Setter
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Irish Setter (Red Setter)
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Kerry Blue Terrier
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Kromfohrländer
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Labradoodle
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Manchester Terrier
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Miniature Poodle
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Papillon (Continental Toy Spaniel )
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Pembroke Welsh Corgi
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Poodle
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Stabyhound ( Stabijhoun )
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Standard Poodle
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Toy Poodle
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Doberman Pinscher, Manchester Terrier, Papillon (Continental Toy Spaniel ), and Standard Poodle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
We are pleased to announce that Laboklin obtained an exclusive European License to perform this important genetic tes from Vet Gen LCC the owner of the European patentt.
Von Willebrand disease (vWD) is probably the most common inherited bleeding disorder in dogs. It is caused by lack of von Willebrand factor which is a protein that plays a key role in the blood clotting process resulting in prolonged bleeding. The disorder occurs in varying degrees of severity ranging from trivial bleeding to excessive life threatening haemorrhages. |
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Clinical Signs |
Symptoms include spontaneous bleeding from the nose, gum and other mucous membranes. Excessive bleeding occurs after an injury, trauma or a surgery. Often dogs don’t show clinical signs until something starts the bleeding, such as nail trimming, teething, spaying, sterilizing, tail docking, cropping or other causes. Bleeding also occurs internally in the stomach, intestines, urinary tracts, the genitals and / or into the joints.
Type I von Willebrand's disease is considered relatively mild when compared to Type II in Scotch Terriers and Shetland Sheep Dogs and Type III in the German Wirehaired pointer, Type II and Type III are much more severe than type I. |
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Description |
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The Mutation-based Test and its Advantages
A new DNA test has now been developed for the type I vWD.
Genetic testing makes it possible to identify whether a dog is clear, carrier or affected. This is vital to eliminate this condition from the breed within 2-3 generations.
The new DNA test can identify the responsible mutation directly.
This DNA test can be done at any age and unambiguously classifies dogs into affected, carriers and clear. The test enables breeders to eliminate the vWD disease gene from the Poodles. Carriers can be clinically normal because of a low penetrance or expressivity of the disease. This information is essential for controlling this disorder in the breed.
Breeders and owners should view vWD as a significant health risk and strive to get rid of the mutated gene. The discovery of the mutation, and the recent development of a DNA test, now provides just that opportunity.
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Trait of Inheritance |
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vWD Type I is transmitted as autosomal incomplete dominant trait . Dogs with vWD Type 1 may experience mild to moderate bleeding tendencies, however, not all dogs with the mutation will exhibit symptoms
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Inheritance : AUTOSOMAL
Dominant with Incomplete Penetrance
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop von Willebrand disease Type I (vWD I). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / vWDI [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
These dogs may exhibit mild to moderate bleeding tendencies, but not all will show clinical signs.
Affected
Genotype: vWDI / vWDI [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
Dogs with two copies of the mutation are more likely to show more severe symptoms.
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Price
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£ 48.00 (including VAT)
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