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Exercise Induced Collapse ( EIC )
Test number: 8152
Gene: EIC
Price: £ 66.00 (including VAT)
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NEW EUROPEAN EXCLUSIVE LICENSE 10/12/2008 |
We are pleased to announce that LABOKLIN has now an Exclusive License to offer the EIC DNA test (Exercise Induced Collapse) in Labrador Retriever in Europe. |
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Breeds
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Boykin Spaniel
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Chesapeake Bay Retriever
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Clumber Spaniel
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Curly Coated Retriever
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German Wirehaired Pointer
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Labradoodle
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Labrador Retriever
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Old English Sheepdog (Bobtail)
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Pembroke Welsh Corgi
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Clumber Spaniel, Curly Coated Retriever, and Labrador Retriever.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
Exercise Induced Collapse is an inherited condition that affects Labrador Retriever and related breeds. Affected dogs can endure mild to moderate exercise but after 5 to 20 minutes of heavy exercise with extreme excitement, the dog shows weakness and then collapse. Severely affected dogs may collapse whenever they are exercised to this extend – other dogs only exhibit collapse episodes sporadically.
Signs of EIC are not typically seen until the dog begin intense training. First symptoms are usually noted between 5 months and 3 years of age. However, it is confirmed that some affected dogs did not have collapse episodes until as late as age 10. |
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Clinical Signs |
The first symptom noted during an episode is usually a rocking or forced gait. The rear limbs then become weak and unable to support weight. Many affected dogs will continue to run while dragging their back legs. Some dogs appear uncoordinated, especially in the rear limbs, with a wide-based, long, loose stride rather than the sort stiff strides typically associated with muscle weakness. In some dogs the rear limb collapse progresses to forelimb weakness and occasionally to a total inability to move. Some dogs appear to have a loss of balance and may fall over, particularly as they recover from complete collapse. Most collapsed dogs are totally conscious and alert, still trying to run and retrieve, but as many as 25% of affected dogs will appear stunned or disoriented during the episode.
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Description |
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The the genetic mutation responsible for susceptibility to EIC was identified at the University of Minnesota (EE Patterson, JR Mickelson, KM Minor). This is a mutation based test that classifies dogs as Clear, Carriers and Affected. Clear and Carrier dogs will not show signs of EIS, however carriers can pass the mutation to their offspring. The test provides reliable information to dog breeders and owners that enable them to control the spread of the mutation in the breed.
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Trait of Inheritance |
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EIC follows an autosomal recessive trait of inheritance.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Exercise Induced Collapse ( EIC ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / EIC [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Exercise Induced Collapse ( EIC ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: EIC / EIC [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Exercise Induced Collapse ( EIC ) and will pass the mutant gene to its entire offspring
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Price
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£ 66.00 (including VAT)
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