LABOKLIN (UK)| Genetic Diseases | Dogs| Glycogen Storage Disease (GSDllla)
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Glycogen Storage Disease (GSDllla)

Test number: 8156 (this test number replaces the old 8156D)
Gene: GSD
Price: £ 48.00 (including VAT)
Breed
Curly Coated Retriever .
The Disease
Glycogen storage disease is a glycogen metabolism disorder caused by deficiency of the glycogen debranching enzymes (AGL) and this results in accumulation of glycogen in the liver and other organs. Glycogn Storge Disease Type llla (GSDlla) affects Curly Coated Retriever.
Clinical Signs
Affected dogs show less symptoms in early life but older dogs exhibit exercise intolerance, lethargy, episodic hypoglycemia and prolonged recovery from exercise and collapse.
Trait of Inheritance
Glycogen storage disease type IIIa has an autosomal recessive trait of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Glycogen Storage Disease (GSDllla). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / GSD [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Glycogen Storage Disease (GSDllla) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: GSD / GSD [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Glycogen Storage Disease (GSDllla) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

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