LABOKLIN (UK)| Genetic Diseases | Dogs| Achromatopsia (day blindness) / ACHM
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Achromatopsia (day blindness) / ACHM

Test number: 8166 (this test number replaces the old 8258D)
Gene: ACHM
Price: £ 48.00 (including VAT)
Breeds
German Shepherd , Labrador Retriever .
The Disease
Day Blindness in the Labrador Retriever and Labrador crosses is an autosomal recessive inherited diease. Thw condition, also known as Achromatopsia (ACHM) which is present at birth. Clinical symptoms become apparent at approximately 8-10 weeks of age. The disease causes the dogs to be unable to see in bright/daylight conditions. In lower light conditions, e.g. At night, Labradors with this disease have visual function comparable to normal dogs.

The disease is found in Labrador and Labrador crosses such as Labradoodle.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Achromatopsia (day blindness) / ACHM. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / ACHM [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Achromatopsia (day blindness) / ACHM but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: ACHM / ACHM [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Achromatopsia (day blindness) / ACHM and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

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