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Familial Nephropathy (FN) / Hereditary Nephropathy
Test number: 8192 (this test number replaces the old 8192D)
Gene: FN
Price: £ 48.00 (including VAT)
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Breed
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English Springer Spaniel
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The Disease |
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The Familial or Hereditary Nephropathy (FN) is a juvenile-onset fatal kidney disease in English Springer Spaniels. The renal disease caused by FN invariably is progressive and ultimately fatal. Dogs with FN typically develop chronic renal failure between 6 month and 2 years of age, with eventual and sometimes rapid destruction of both kidneys. The first clinical signs are excessive water consumption, growth rate or loss in weight, reduced appetite, and vomiting.
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Description |
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By DNA testing, the responsible mutation can be shown directly. This method provides a test with a very high accuracy and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
* test will be performed by a partner lab
The DNA test does not provide informations about onset of clinical signs and the severity of disease symptoms.
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Trait of Inheritance |
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FN in English Springer Spaniel is caused by a type IV collagen defect, which can be detected by a mutation-based gene test.
FN is inherited as an autosomal recessive trait. So there are three conditions a dog can be: it can be clear (genotype N/N or homozygous normal) meaning that it does not carry the mutation and will not develop FN. Since it also cannot pass the mutation onto its offspring, it can be mated to any other dog.
A dog which has one copy of the gene with the mutation and one copy without the mutation is called a carrier or heterozygous (genotype N/FN); while it will not be affected by FN, it can pass the mutation onto its offspring and should therefore only be mated to clear dogs.
Dogs that develop FN have two gene copies with the mutation (genotype FN/FN or homozygous affected); they will always pass the mutated gene onto their offspring and should also be mated only to clear dogs.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Familial Nephropathy (FN) / Hereditary Nephropathy. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / FN [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Familial Nephropathy (FN) / Hereditary Nephropathy but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: FN / FN [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Familial Nephropathy (FN) / Hereditary Nephropathy and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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