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Hereditary Nephritis / Samoyed Hereditary Glomerulopathy
Test number: 8192DS
Gene Name: HN
Short Name: HN
Price: £ 48.00 (including VAT)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Samoyed.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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Description |
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Hereditary nephritis / glomerulonephropathy in Samoyed is a recessive, X-linked hereditary disease that affects young male dogs more severely than females. Affected males and females spontaneously develop proteinuria, but only males progress to renal failure. Affected male puppies usually show symptoms of the disease by 2 to 3 months of age. They start to lose weight noticeably and kidney function deteriorates rapidly, resulting in death by an early age (approximately 1 year). Females who carry the disease also lose weight and develop proteinuria between two and three months of age, but the disease is less severe and does not progresses to kidney failure.
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Trait of Inheritance |
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X-Chromosomal Dominant with Variable Penetrance
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: HN [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / HN [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: HN / HN [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring
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Price
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£ 48.00 (including VAT)
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| See also: |
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