|
JEB (Junctional Epidermolysis bullosa)
Test number: 8198 (this test number replaces the old 8198D)
Gene: JEB
Price: £ 48.00 (including VAT)
|
|
|
|
|
|
Breed
|
|
German Shorthair Pointer
.
|
|
|
|
The Disease |
 |
|
EB (Junctional Epidermolysis bullosa) is a blistering disorder of the skin and mucous membranes in which tissue separation occurs within the lamina lucida of the basement membrane zone at the dermal-epidermal junction. Affected dogs show erosion and encrustation in the field of the balls, knees, elbows, ankle joints, carpal bones, hips, lips and tongue.
|
|
|
|
|
Description |
|
The genetic test detects a SNP mutation that is inherited together with the responsible mutation. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
The DNA test does not provide informations about onset of clinical signs and the severity of disease symptoms.
|
|
|
|
|
Trait of Inheritance |
|
JEB in German Pointers is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease.
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
| |
|
|
|
|
|
clear
|
 |
clear
|
 |
100% clear
|
| |
|
|
|
|
|
clear
|
|
carrier
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
clear
|
|
affected
|
|
100% carriers
|
| |
|
|
|
|
|
carrier
|
|
clear
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
carrier
|
|
carrier
|
|
25% clear + 25% affected
+ 50% carriers
|
| |
|
|
|
|
|
carrier
|
|
affected
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
clear
|
|
100% carriers
|
| |
|
|
|
|
|
affected
|
|
carrier
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
affected
|
|
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop JEB (Junctional Epidermolysis bullosa). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / JEB [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop JEB (Junctional Epidermolysis bullosa) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: JEB / JEB [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop JEB (Junctional Epidermolysis bullosa) and will pass the mutant gene to its entire offspring
|
|
|
| |
| |
|
Price
|
|
£ 48.00 (including VAT)
|
|
|
 |
|
|
|
|
