LABOKLIN (UK)| Genetic Diseases | Horses| Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)
prices in Pound
 
  Home
  News and offers
  Genetic Diseases
Dogs
Cats
Horses
Cattle
Pigs
Rabbit
Sheep
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Organs / Parameters
  Allergy testing
  Pathology
  Downloads & Order
  Order Kit Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS
  facebook
 
**NEW**



Maine Coon Special offer:
8 DNA tests for just £84.95 incl VAT
Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs) 
**NEW**



Bengal Special offer:
4 Bengal Specific DNA tests for just £72.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups) 



British Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups)



Burmese Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups



Birman Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups)



Maine Coon Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def + F11 + Blood Groups)



Ragdoll Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood Groups)



Norwegian Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood Groups)



Feline Special Offer:
8 cat DNA tests for just £84.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
new test:      Lysosomal Storage Diseases (LSD) in Dalmatian and Doberman  
new Kennel Club DNA testing schemes with LABOKLIN:
   Osteochondrodysplasia (OCD) / Skeletal Dwarfism in Miniature Poodles
  DINGS2: Deafness with Vestibular Dysfunction in Doberman
   Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel


Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)

Test number: 8231 (this test number replaces the old 8301HGD)
Gene: LFS
Price: £ 48.00 (including VAT)
Breeds
Arabian , Quarab .
The Disease
Lavender Foal Syndrome (LFS) is a lethal genetic disorder with neurological symptoms found in foals of Arabian horses, it is also known as Coat Colour Dilution Lethal (CCDL).

Affected foals are often delivered with difficulty (Dystocia), at birth, foals are unable to stand or sit upright, they extend their limbs, legs and back rigidly, the head and neck are drawn back, convulsions or spasms and rapid eye movements. it is thought that neurological symptoms are due to brain legion and disturbance of the Central nervous System.

The coat colour of most but not all affected foals is described to be very pale chestnut, lavender or light purple, pewter, pale pink or even silvery . The eyes have been described as grayish brown or having blue tint.

Affected foals will die, however, they are usually euthanized within few days of birth on humane grounds.

There is no treatment for the disease.

Lavender Foal Syndrome is only found in Arabian horses, particularly in Egyptian Arabian where prevalence is estimated at about 10%.

Trait of Inheritance
The trait of inheritance is Autosomal Recessive which means that only horses with two copies of the mutated gene (LFS/LFS) will be affected by the disease. Horses carrying one copy of the mutated gene and one copy of the normal gene (N/LFS) will not develop the disease but they can pass the mutation to their offspring. Genetic testing enables you to identify clear horses from carriers.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.

It is very unlikely that the horse will develop Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL). The horse will never pass the mutation to its offspring, and therefore it can be bred to any other horse.

 

Carrier

Genotype: N / LFS [ Heterozygous ]

The horse carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the horse will develop Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear horses.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: LFS / LFS [ Homozygous mutant ]

 

The horse carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The horse is likely to develop Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL) and will pass the mutant gene to its entire offspring
Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.

Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

To order:




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:

 
 
Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Organs / Parameters  |   Allergy testing  |   Pathology  |   About us  |   Contact Us
LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007-2023 Laboklin (UK)
Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Tel. 0161 282 3066