LABOKLIN (UK)| Genetic Diseases | Cats| Alpha-Mannosidosis (AMD)

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Alpha-Mannosidosis (AMD) Test number: 8239 Gene: AMD Price: £ 48.00 (including VAT)

Breed

Persian .

The Disease

Alpha-mannosidosis is a rare inherited disease of cats caused by an abnormal lysosomal storage within cells.

The Alpha-mannosidosis (AMD) is a lysosomal storage disorder caused by a deficiency of the enzyme Alpha-D-mannosidase. The causative mutation prevents formation of the enzyme, resulting in an intracellular accumulation of mannose-rich oligosaccharides

Clinical Signs

Clinical symptoms include skeletal abnormalities, neurological signs such as ataxia and tremors, and corneal and lenticular opacities.

Stillbirths and neonatal deaths may occur in Persian litters and many affected animals may not survive the first 6 months of life.

Trait of Inheritance

Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Alpha-Mannosidosis (AMD). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / AMD [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Alpha-Mannosidosis (AMD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: AMD / AMD [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Alpha-Mannosidosis (AMD) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

2-3 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

Dam

Offspring