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Breed
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Lagotto Romagnolo
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Lagotto Romagnolo.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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The Lagotto Romagnolo storage disorder is a genetic disroder characterized by movement in-coordination, which is seen as a staggering, uncoordinated gait. Other symptoms such as involuntary eye movements (nystagmus) and behavioral changes, such as aggression, have also been seen in affected dogs. The onset of the disease varies from 4 months to 4 years. The condition is progressive and symptoms in affected worsens to a degree where they need to be euthanized.
In affected dogs, storage materials accumulates in the cerebellar neurons and other cells leading to dysfunction and cell death. |
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Trait of Inheritance |
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autosomal-recessive inheritance,
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Lagotto Storage Disease (LSD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LSD [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog may or may show symptoms of the Lagotto Storage Disease (LSD). The dog can pass the mutation on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected
Affected
Genotype: LSD / LSD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Lagotto Storage Disease (LSD) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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