LABOKLIN (UK)| Genetic Diseases | Dogs| Fanconi Syndrome (FS)
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Fanconi Syndrome (FS)

Test number: 8272
Gene: FS
Price: £ 54.00 (including VAT)
Breed
Basenji .
The Disease
Fanconi Syndrome is a genetic disease of the kidney.

In affected dogs, the Kidney's proximal tubules fail to reabsorb vitamins, minerals, sugars and other nutrients back into the body, instead they are dumped into the urine. The loss of these nutrients results in dehydration and electrolyte imbalances along with other problem.

Fanconi Syndrome is considered as one of the most common inherited disease in Basenji .

Symptoms include polydipsia (excessive drinking), polyuria (excessive urination), and glucose in the urine (glucosuria). Untreated Fanconi Syndrome will lead to muscle wasting, acidosis and poor condition, and eventually death.

The age of onset is typically between four and eight years of age, however, symptoms have been seen in dogs as young as two years old and as old as eleven years.

The disease is progressive. The progression rate is variable.

* test performed by partner lab

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Fanconi Syndrome (FS). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / FS [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Fanconi Syndrome (FS) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: FS / FS [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

Affected dogs are at a high risk of developing Fanconi Syndrome at some point in their lives
Sample Requirements
Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube
Turnaround
4-5 weeks
Price
£ 54.00 (including VAT)

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