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1 ) Leonberger Polyneuropathy 1 ( LPN1)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Leonberger.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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The type 1 neuropathy (LPN1) in Leonberger starts at the age of 2-4 year and shows a severe progression. The symptoms of this polyneuropathy include wobbly gait and paralysis especially from the backhand. Affected dogs are not able to stand up in the final stage of the disease. Breathing noises, strange barking voice and difficulties in swallowing are other typical symptoms. The causative mutation causes around 20% of all polyneuropathy cases in the Leonberger breed.
In Leonberger there two more mutations known to cause the disease LPN2 and LPPN3, the three tests are recommended for complete diagnosis:
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2 ) Leonberger Polyneuropathy 2 ( LPN2 )
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Leonberger.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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The type 2 neuropathy (LPN2) in Leonberger starts at the age of 2-4 year and shows a severe progression. The symptoms of this polyneuropathy include wobbly gait and paralysis especially from the backhand. Affected dogs are not able to stand up in the final stage of the disease. Breathing noises, strange barking voice and difficulties in swallowing are other typical symptoms.
In Leonberger there two more mutations known to cause the disease LPN1 and LPPN3, the three tests are recommended for complete diagnosis:
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3 ) Leukoencephalomyelopathy ( LEMP )
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Breeds
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Great Dane
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Leonberger
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Rottweiler
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Leonberger, and Rottweiler.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
LEMP is an autosomal recessive inherited disease of the central nervous system ( CNS ), which is characeterised by progressive gait abnormalities including paw dragging and knuckling. dogs show lacks of coordination and generalised ataxia. As the disease progresses, affected dogs may become increasingly immobile within a few months. Researchers from the university of Bern and the university of Minnesota were able to identify two causative genetic mutations, one of them affects Leonbergers, and a second one which affects Rottweilers and Great Danes. A test is now available at Laboklin.
Please note that the LEMP variant is also referred to as the 'D' by other labs, this is the same, it is just another nomenclature for the LEMP variant, and so:
- Clear: N/N (same)
- Carrier: N/LEMP = N/D
- Affected: LEMP/LEMP = D/D
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Leukoencephalomyelopathy ( LEMP ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LEMP [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Leukoencephalomyelopathy ( LEMP ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LEMP / LEMP [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Leukoencephalomyelopathy ( LEMP ) and will pass the mutant gene to its entire offspring
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4 ) Laryngeal Paralysis - Polyneuropathy ( LPPN3 )
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Breeds
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Labrador Retriever
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Leonberger
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St. Bernard
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Leonberger.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
The LPPN3 is another mutation that causes Laryngeal Paralysis - Polyneuropathy in Leonberger. It has also been found in Labrador Saint Bernard. Affected leonberger puppies usually develop severe symptoms of laryngeal paralysis at young age including breathing difficulty which is often loud and gagging, difficulty in swallowing food, hanges in barking frequency and quality, high-stepping and uncoordinated gait, stumbling and tripping, exercise intolerance, and muscle atrophy. In Leonberger there two more mutations known to cause the disease LPN1 and LPN2, the three tests are recommended for complete diagnosis:
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Trait of Inheritance |
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LPPN3 is inherited in autosomal recessitive mode which means that two copies of the mutation are required for the dog to develop symptoms of the disease
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LPPN3 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LPPN3 / LPPN3 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ) and will pass the mutant gene to its entire offspring
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Price
for the above 4 tests
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£ 138.00 (including VAT)
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