LABOKLIN (UK)| Genetic Diseases | Dogs| Mucopolysaccharidosis type IIIb ( MPS3b )
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Mucopolysaccharidosis type IIIb ( MPS3b )

Test number: 8299
Gene: MPS3b
Price: £ 48.00 (including VAT)
Breed
Schipperke .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Schipperke.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

Description

Mucopolysaccharidosis type IIIb ( MPS3B ) is an inherited lysosomal storage disease affecting the Schipperke breed. It is also known as “Sanfilippo syndrome type IIIb”. Lysosomes are important cell structures that disassemble large molecules using enzymes in order to recycle or dispose of the molecules. In the case of Mucopolysaccharidosis type IIIb disease, the heparan sulfate molecules cannot be disassembled due to a defective enzyme, and therefore the undegraded molecule accumulates in the lysosomes. Heparan sulfate is an important component of structures like bones and cartilage and is known to be implicated in cell-to-cell communications, especially in the brain. Typical symptoms of this disease include tremor, difficulties in balancing, walking and negotiating obstacles and falling to both directions. Furthermore, the symptoms are progressive and initial problems with balance become worse. The age of onset varies between 2-4 years. Affected dogs usually are euthanized 1-2 years after first clinical signs.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

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