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Canine Multi-Focal Retinopathy (CMR 1/2/3)
Test number: 8330
Gene: CRM
Price: £ 48.00 (including VAT)
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Breeds
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American Bulldog
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Australian Shepherd
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Boerboel (South African mastiff)
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Bull Mastiff
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Bulldog (English)
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Cane Corso (Italian)
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Continental Bulldog ( Conti )
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Coton de Tulear
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Dogue de Bordeaux (French Mastiff)
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English Mastiff
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Finnish Lapphund
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French Bull Dog
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Pyrenean Mountain Dog (Great Pyrenees)
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Lapponian Herder
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Mastiff
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Miniature American Shepherd
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Perro de Presa Canario (Dogo Canario)
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Swedish Lapp Hund
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The Disease |
Canine Multi-focal Retinopathy (CMR) is a recently identified recessively inherited eye disease observed in a number of dog breeds which is characterised by the presence of numerous distinct (i.e. multi-focal), roughly circular patches of elevated retina with accumulation of material that produces gray-tan-pink colored lesions. These lesions, looking somewhat like blisters, vary in location and size, although typically they are present in both eyes of the affected dog.Discrete areas of tapetal hyper-reflectivity might also be seen.
The disease generally develops in young dogs before 4 months and might progress slowly, might appear to heal, or might even appear and then go away again. Some dogs affected with CMR do not show clinical symptoms of disease until later in life. Some lesions disappear with no remaining sign, while some lesions leave a wrinkled area. Some leave the lasting lesion of a blister formation. Most dogs exhibit no noticeable problem with vision despite their abnormal appearing retinas. And in almost all cases, CMR does not progress significantly over time. The disease seems to have a consistent pattern among the breeds identified so far, although lesions in the Coton de Tulear are often more serious and seem to remain longer than in some of the other CMR-affected breeds. In rare severe cases, the clinical diagnosis could be confused with progressive retinal atrophy (PRA).
Please note that Lapponian Herder can be affected two other forms of PRA, the IFT122-PRA and the prcd PRA |
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Trait of Inheritance |
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autosomal recessive mode
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Canine Multi-Focal Retinopathy (CMR 1/2/3). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CRM [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Canine Multi-Focal Retinopathy (CMR 1/2/3) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CRM / CRM [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Canine Multi-Focal Retinopathy (CMR 1/2/3) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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