LABOKLIN (UK)| Genetic Diseases | Cats| Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA)

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Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA) Test number: 8331 Gene: PRA-b Price: £ 48.00 (including VAT)

Breed

Bengal (Leopard cat) .

The Disease

Bengal Progressive Retinal Atrophy (PRA-b) is an inherited eye disease affecting the Bengal cat. The disease is characterised by progressive blindness that starts around the age of 7 weeks and slowly progresses until the cat has very compromised vision around the age of two years. The disease develps at different rates in the different cats. The pupil in affected cats is more dilated compared to cats with normal vision. Affected cats tend to carry their whiskers forward. Blind cats tend to have more difficulty at night, sometimes becoming more vocal and more attached to their owners.

The trait of inheritance is autosomal recessive which means that the disease can affect both male and female cats and that a cat can only develop the disease if it inherits two copies of the mutation one from the mother and one from the father. Carries do not develp the disease but they can pass the mutation to offspring and therefore they should only be bred to clear cats. DNA testing enables breeders to breed healthy kittens.

The test is offered in cooperation with the Veterinary Genetic Laboratory at the University of California.

Trait of Inheritance

Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / PRA-b [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: PRA-b / PRA-b [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

1-2 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

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Offspring