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Larynx / Laryngeal Paralysis ( LP )
Test number: 8361
Gene: LP
Price: £ 48.00 (including VAT)
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Breeds
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Bull Terrier
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Miniature Bull Terrier
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Description |
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Laryngeal paralysis is an inherited disease affecting Bull Terriers and characterised by difficulties in breathing, especially during physical activity, and may cause death by suffocation in severe cases. Larynx paralysis may require surgery to relieve the difficulties in breathing. Clinical signs include decreasing exercise tolerance, progressive laryngeal stridor, voice impairment, episodes of breathing difficulties and collapsing. In the Bull Terrier and Miniature Bull Terrier, a genetic variant has been identified as a major genetic risk factor for an early onset form of laryngeal paralysis. Dogs which are homozygous for the variant are at 23 fold increased risk of developing the disease, and therefore, dogs carrying the varian should be bred with clear dogs to avoid producing puppies with two copies of the variant.
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Trait of Inheritance |
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autosomal recessive mode of inheritance with variable penetrance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
This animal does not carry
the genetic defect and has no elevated risk of developing
LD. The dog cannot pass the genetic defect to its offspring.
Carrier
Genotype: N / LP [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
This animal carries one copy of the defective gene. The dog has no elevated risk of developing LP. However, the defect will be passed to its offspring with a probability of 50%. Such an animal should only be mated to a clear Animal.
Affected
Genotype: LP / LP [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
This animal carries two copies of the defective gene and has an elevated risk for LP. Many of these dogs will develop LP during the first years of life.
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Price
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£ 48.00 (including VAT)
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