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Primary Open Angle Glaucoma (POAG)
Test number: 8452 (this test number replaces the old 8236D)
Gene: POAG
Price: £ 48.00 (including VAT)
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Breeds
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Basset Hound
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Basset Fauve de Bretagne (Petit)
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Beagle
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Norwegian Elkhound
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Petit Basset Griffon Vendeen
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Basset Hound, Basset Fauve de Bretagne (Petit), and Norwegian Elkhound.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
A primary open angle glaucoma is a genetic dysfunction of the connective tissue in the eye. Thereby, the aqueous fluid is blocked and the pressure of the eyeball rises. Ultimately, the optic nerve and the retina are damaged leading from partial to complete blindness.
Symptoms include widened pupils, red eyeballs, cloudy cornea and increased eye pressure. Raising eye-pressure causes pain, which leads to the dog loses it's appetite, scratches the eyes, rubbing it's head on walls and exhibit aggressive behaviour.
Early diagnosis allows treatment in decreasing the eye-pressure constantly and thereby preventing damage on the optic nerve and retina. |
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Trait of Inheritance |
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Autosomal recessive
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Primary Open Angle Glaucoma (POAG). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / POAG [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Primary Open Angle Glaucoma (POAG) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: POAG / POAG [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Primary Open Angle Glaucoma (POAG) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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