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Breeds
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Alaskan Malamute
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Bobtail
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Old English Sheepdog (Bobtail)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Old English Sheepdog (Bobtail).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Primary ciliary dyskinesia (PCD) is an autosomal-recessive genetic disease characterized by recurrent infections of the respiratory tract as well as reduced male fertility. Around 50% of the affected dogs develop situs inversus (Kartagener syndrome). The underlying cause is a motility defect in the respiratory cilia responsible for airway clearance and in the flagella responsible for propelling sperm cells.
In Old English Sheepdod the disease is caused by a mutation in the CCDC39 gene, while in Alaskan Malamute it is caused by mutation in NME5 gene |
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Clinical Signs |
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Symptoms include chronic inflammation of upper and lower airways, coughing, nasal discharge, wheezing, bronchopneumonia and inflamation of the ear.
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Trait of Inheritance |
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Autosomal recessive trait of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Primary ciliary dyskinesia (PCD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / PCD [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Primary ciliary dyskinesia (PCD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: PCD / PCD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Primary ciliary dyskinesia (PCD) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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