Clear (N/N)
Description: Dogs with this genotype have the lowest risk of developing PLN. They do not inherit any copies of the PLN-associated genetic mutations, making them the least susceptible to the disease.
Transmission: These dogs will not pass the PLN-associated mutation to their offspring. All their puppies will receive a normal (N) allele from them.
Heterozygous (N/PLN)
Description: Dogs with this genotype have a low to intermediate risk of developing PLN. They inherit one copy of the PLN-associated genetic mutation, which increases their risk compared to dogs with no copies but not as much as those with two copies.
Transmission: These dogs have a 50% chance of passing the PLN-associated mutation (PLN) to their offspring. Each puppy has an equal chance of inheriting either the normal (N) allele or the PLN-associated mutation.
Homozygous Positive (PLN/PLN)
Description: Dogs with this genotype have the highest risk of developing PLN. They inherit two copies of the PLN-associated genetic mutations, significantly increasing their susceptibility to the disease.
Transmission: These dogs will pass the PLN-associated mutation to all their offspring. Every puppy will inherit one PLN allele from the homozygous positive parent.
Summary Table
| Genotype | Risk Level | Transmission to Offspring |
|---|
|
N/N (Clear) | Lowest | Will pass only normal (N) alleles | | N/PLN | Low to Intermediate | 50% chance of passing PLN mutation |
| PLN/PLN | Highest | Will pass PLN mutation to all offspring |
