Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Charcot -Marie - Tooth (CMT ) / Demyelinating Polyneuropathy (DM / DPN / DMPN). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CMT [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Charcot -Marie - Tooth (CMT ) / Demyelinating Polyneuropathy (DM / DPN / DMPN) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CMT / CMT [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Charcot -Marie - Tooth (CMT ) / Demyelinating Polyneuropathy (DM / DPN / DMPN) and will pass the mutant gene to its entire offspring
