LABOKLIN (UK)| Genetic Diseases | Dogs| Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia
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Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia

Test number: 8552
Gene: CAT
Price: £ 48.00 (including VAT)
Breed
Beagle .
The Disease
Catalase Deficiency (hypocatalasemia or acatalasia) is a rare inherited disorder that is caused by recessive mutation in the CAT gene which is responsible for the production of the anti-oxidative enzyme catalase.

Catalase enzymes regulates the metabolism of hydrogen peroxide, one of many by-products generated during the respiration process. Affected dogs are particularly sensitive to hydrogen peroxide’s oxidative stress, causing painful

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / CAT [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: CAT / CAT [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia and will pass the mutant gene to its entire offspring
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

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