LABOKLIN (UK)| Genetic Diseases | Dogs| Ichthyosis
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Ichthyosis

Test number: 8555
Gene: ICH
Price: £ 48.00 (including VAT)
Breed
American Bulldog .
The Disease
Ichthyosis is an inherited disease that affects the American Bulldog breed. It is characterised by the presence of dishevelled coat hair shortly after birth, generalized scaling, and sticky brown scales with reddening of the abdominal skin.

A dog can be either clear (N/N), Carrier (N / ICH) or affected (ICH/ICH). Due to the recessive mode of inheritance only Affected (ICH/ICH) dogs will exhibit symptoms of the disease. Clear and Carriers will not display any symptoms, however, carriers can pass the mutation to their offspring and therefore carriers must only be bred to clear dogs to avoid having affected puppies.

A DNA test is now available from Laboklin and can help you to identify if your dog carry the mutation.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / ICH [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: ICH / ICH [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

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