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1 ) Late Onset Ataxia (LOA)
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Breeds
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Jack Russell Terrier.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Late onset ataxia (LOA) in the Parson Russell Terrier is a genetic disease characterised by progressive gait incoordination and loss of balance. Early symptoms are usually seen at the age of 6-12 month, the disease progresses, gait becomes increasingly incoordinated with difficulty in moving around or complete loss of mobility.
This disease is caused by a mutation in the calcium activated neutral proteinase 1 (CAPN1)-gene.
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Trait of Inheritance |
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Recessive trait of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Late Onset Ataxia (LOA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LOA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Late Onset Ataxia (LOA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LOA / LOA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Late Onset Ataxia (LOA) and will pass the mutant gene to its entire offspring
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2 ) Spinocerebellar ataxia (SCA)
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Breeds
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Alpine Dachsbracke
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Fox Terrier
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Patterdale Terrier
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Tenterfield Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Jack Russell Terrier, and Parson Russell Terrier (PRT).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
spinocerebellar ataxia is an inherited disorder of the cerebellum in which affected dogs suffer a poorly coordinated movement, goose-stepping gait when getting excited or when excercised, sometimes there is lack of balance and frequent falling.
* partner lab |
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3 ) Juvenile Brain Disease ( JBD ) / Juvenile Encephalopathy ( Epilepsy )
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Breeds
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Description |
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Juvenile Encephalopathy is a severe brain disorder, with an early onset of around 6-12 weeks. Affected dogs suffer from epileptic seizures, with the disease progressing rapidly causing irreversible brain damage.
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Price
for the above 3 tests
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£ 120.00 (including VAT)
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