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Home   News and offers   Genetic Diseases Dogs Cats Horses Cattle Pigs Rabbit Sheep   Coat Colours / Length   Identity / Parentage   Reptiles & Amphibians   Avian Tests   Profiles / Screening   Infectious Diseases   Organs / Parameters   Allergy testing   Pathology   Downloads & Order   Order Kit Online   About Us   Crufts & Shows   Contact Us   Kennel Club ABS   facebook   **NEW** Maine Coon Special offer: 8 DNA tests for just £84.95 incl VAT Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs)  **NEW** Bengal Special offer: 4 Bengal Specific DNA tests for just £72.00 incl VAT Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups)  British Special offer: 4 Breed Specific DNA tests for just £72.00 incl VAT British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups) Burmese Special offer: 4 Breed Specific DNA tests for just £72.00 incl VAT Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups Birman Special offer: 5 Breed Specific DNA tests for just £72.00 incl VAT Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups) Maine Coon Special offer: 5 Breed Specific DNA tests for just £72.00 incl VAT Maine Coon DNA bundle (HCM1 + SMA + PK-Def + F11 + Blood Groups) Ragdoll Special offer: 5 Breed Specific DNA tests for just £72.00 incl VAT Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood Groups) Norwegian Special offer: 4 Breed Specific DNA tests for just £72.00 incl VAT Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood Groups) Feline Special Offer: 8 cat DNA tests for just £84.95 including VAT HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels   new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel new test:      Lysosomal Storage Diseases (LSD) in Dalmatian and Doberman   new Kennel Club DNA testing schemes with LABOKLIN:    • Osteochondrodysplasia (OCD) / Skeletal Dwarfism in Miniature Poodles    • DINGS2: Deafness with Vestibular Dysfunction in Doberman    • Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel Irish (Red and White) Setter DNA bundle (CLAD + Krabbe + rcd1-PRA + rcd4-PRA) Test number: 8638 Price: £ 138.00 (including VAT) for all 4 tests   1 ) CLAD (Canine Leukocyte Adhesion Deficiency) Breeds Irish Red and White Setter , Irish Setter (Red Setter) . Kennel Club This test is part of the Official UK Kennel Club DNA Testing Scheme in Irish Setter (Red Setter). for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club. In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so. important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications. The Disease Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease found in Irish Setters. The condition is caused by mutation in a gene encoding a leucocyte surface molecule, leading to a dysfunction of the granulocytes. Therefore, the cell-cell adhesion events are disturbed. Because their healing capacities are impaired, the affected dogs show severe infections of omphalophlebitis, skin infections, osteomyelitis and gingivitis. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics. Description This is a mutation-based gene test, which offers many advantages over other methods The genetic defect leading to this disease has been identified. By DNA testing, the responsible mutation can be identified directly. This method ensures that the test result is highly accuracy and can be applied at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This information is essential for controlling the disease within the breed, as carriers are capable of spreading the disease to next generations, while it can not be identified by means of common laboratory diagnostic. If a particularly valuable dog turns out to be a carrier, it can be bred to a clear animal, and then the non-carrier puppies can be saved for the next round of breeding. But given the lethal nature of this disease, it is the best to select against carriers who are not superlative dogs in order to entirely eliminate the gene from the line within two or three generations Trait of Inheritance CLAD is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease. Inheritance : AUTOSOMAL RECESSIVE trait   Sire   Dam   Offspring           clear clear 100% clear           clear carrier 50%  clear + 50% carriers           clear affected 100% carriers           carrier clear 50%  clear + 50% carriers           carrier carrier 25% clear + 25% affected + 50% carriers           carrier affected 50% carriers + 50% affected           affected clear 100%  carriers           affected carrier 50% carriers + 50% affected           affected affected 100% affected   Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene. It is very unlikely that the dog will develop CLAD (Canine Leukocyte Adhesion Deficiency). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.   Carrier Genotype: N / CLAD [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene. It is very unlikely that the dog will develop CLAD (Canine Leukocyte Adhesion Deficiency) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)   Affected Genotype: CLAD / CLAD [ Homozygous mutant ]   The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring. The dog is likely to develop CLAD (Canine Leukocyte Adhesion Deficiency) and will pass the mutant gene to its entire offspring Sample Requirements Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Turnaround 1-2 weeks   2 ) Globoid Cell Leukodystrophy (Krabbe Disease) Breeds Cairn Terrier , Irish Setter (Red Setter) , West Highland White Terrier . The Disease Globoid cell leukodystrophy or Krabbe disease is a severe, autosomal recessive dirsorder resulting from a deficiency of galactocerebrosidase (GALC) activity whereby the white matter is degenerated. Clinically, the symptoms appear between the 1st and 3rd months of age. Weakness of the limbs and tremors appear first, followed by muscular atrophy and neurological degeneration. The affected dogs may live until 8 or 9 months of age, when the symptoms become so severe that the dog is usually euthanized. Pathological studies of the white matter from affected dogs show characteristic globoid cells and loss of myelin. Description This is a mutation-based gene test, which offers many advantages over other methods Progress in molecular genetics has allowed the identification of the gene mutation responsible for Globoid Cell Leukodystrophy (Krabbe) in West Highland White and Cairn Terriers. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic. If a particularly valuable dog turns out to be a carrier, it can be bred to a non-affected animal, and non-carrier puppies can be saved for the next round of breeding. Trait of Inheritance Globoid Cell Leukodystrophy (Krabbe) in West Highland White and Cairn Terriers is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease. Inheritance : AUTOSOMAL RECESSIVE trait   Sire   Dam   Offspring           clear clear 100% clear           clear carrier 50%  clear + 50% carriers           clear affected 100% carriers           carrier clear 50%  clear + 50% carriers           carrier carrier 25% clear + 25% affected + 50% carriers           carrier affected 50% carriers + 50% affected           affected clear 100%  carriers           affected carrier 50% carriers + 50% affected           affected affected 100% affected   Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene. It is very unlikely that the dog will develop Globoid Cell Leukodystrophy (Krabbe Disease). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.   Carrier Genotype: N / GLD [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene. It is very unlikely that the dog will develop Globoid Cell Leukodystrophy (Krabbe Disease) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)   Affected Genotype: GLD / GLD [ Homozygous mutant ]   The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring. The dog is likely to develop Globoid Cell Leukodystrophy (Krabbe Disease) and will pass the mutant gene to its entire offspring Sample Requirements Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Turnaround 2-3 weeks   3 ) Progressive Retinal Atrophy (rcd1 PRA) Breeds Irish Red and White Setter , Irish Setter (Red Setter) . Kennel Club This test is part of the Official UK Kennel Club DNA Testing Scheme in Irish Setter (Red Setter). for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club. In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so. important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications. The Disease Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated. Pups show signs of night-blindness by 6 weeks of age. By the age of 1-2 years most affected dogs are completely blind. Description Progress in molecular genetics has allowed the identification of the gene mutation responsible for PRA. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed. Trait of Inheritance rcd1 PRA follows an autosomal recessive trait of inheritance. Since vision loss might be recognised first when the dog is several years old, it is important to determine the actual status of the dog before breeding it. Inheritance : AUTOSOMAL RECESSIVE trait   Sire   Dam   Offspring           clear clear 100% clear           clear carrier 50%  clear + 50% carriers           clear affected 100% carriers           carrier clear 50%  clear + 50% carriers           carrier carrier 25% clear + 25% affected + 50% carriers           carrier affected 50% carriers + 50% affected           affected clear 100%  carriers           affected carrier 50% carriers + 50% affected           affected affected 100% affected   Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene. It is very unlikely that the dog will develop Progressive Retinal Atrophy (rcd1 PRA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.   Carrier Genotype: N / rcd1-PRA [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene. It is very unlikely that the dog will develop Progressive Retinal Atrophy (rcd1 PRA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)   Affected Genotype: rcd1-PRA / rcd1-PRA [ Homozygous mutant ]   The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring. The dog is likely to develop Progressive Retinal Atrophy (rcd1 PRA) and will pass the mutant gene to its entire offspring Sample Requirements Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Turnaround 2-3 weeks   4 ) Progressive retinal atrophy ( rcd4-PRA) / LOPRA Breeds Australian Cattle Dog , Bolonka Zwetna (Tsvetnaya Bolonki) , Cavapoo , Cockapoo (English) , Cockapoo (American) , Dwarf poodle , English Setter , Gordon Setter , Irish Red and White Setter , Irish Setter (Red Setter) , Labradoodle , Miniature Poodle , Old Danish Pointing Dog , Polish Lowland sheepdog , Poodle , Small Munsterlander , Standard Poodle , Tatra Shepherd Dog (POP) , Tibetan Terrier , Toy Poodle . Kennel Club This test is part of the Official UK Kennel Club DNA Testing Scheme in English Setter, Gordon Setter, Irish Setter (Red Setter), Standard Poodle, and Tibetan Terrier. for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club. In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so. important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications. The Disease Progressive retinal atrophy (PRA) is a major hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated. One can distinguish between late onset forms of PRA and early onset (whelp-age) dysplastic changes. The clinical and ophthalmologic signs of both forms are similar. Affected dogs suffer from bilateral Mydriasis, the reflection of the Tapetum lucidum is increased and the retinal vascular network appears atrophic. The rcd4 PRA is another form of PRA, it is also known as LOPRA (Late Onset PRA) the age of onset of dogs with LOPRA varies from few years of age (2-3 years) up to old age (10-11 years) Trait of Inheritance Autosomal recessive Inheritance : AUTOSOMAL RECESSIVE trait   Sire   Dam   Offspring           clear clear 100% clear           clear carrier 50%  clear + 50% carriers           clear affected 100% carriers           carrier clear 50%  clear + 50% carriers           carrier carrier 25% clear + 25% affected + 50% carriers           carrier affected 50% carriers + 50% affected           affected clear 100%  carriers           affected carrier 50% carriers + 50% affected           affected affected 100% affected   Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene. It is very unlikely that the dog will develop Progressive retinal atrophy ( rcd4-PRA) / LOPRA. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.   Carrier Genotype: N / rcd4 [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene. It is very unlikely that the dog will develop Progressive retinal atrophy ( rcd4-PRA) / LOPRA but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)   Affected Genotype: rcd4 / rcd4 [ Homozygous mutant ]   The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring. The dog is likely to develop Progressive retinal atrophy ( rcd4-PRA) / LOPRA and will pass the mutant gene to its entire offspring Sample Requirements Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Turnaround 2-3 weeks Price for the above 4 tests £ 138.00 (including VAT) To order: Download Order Form from this link Complete the order form and send it together with your samples to the following address: Laboklin (UK),   Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or  email: info@laboklin.co.uk. If you are sending swab samples, please follow the instructions on this link . If you have any queries, please contact us on 0161 282 3066 new test: Androgen Insensitivity Syndrome (AIS) new test: ACAN Dwarfism (Chondrodysplasia) new test: Predictive Height Test ( LCORL) new test: Tractability new test: Coat colour Sunshire Dilution See also: Progressive Retinal Atrophy (Dominant PRA) Globoid Cell Leukodystrophy (Krabbe Disease) CSNB (Congenital Stationary Night Blindness) CLAD (Canine Leukocyte Adhesion Deficiency) von Willebrand disease Type II (vWD II) PK Deficiency (Pyruvate Kinase Deficiency) Fucosidosis PFK Deficiency (Phosphofructokinase deficiency / PFKD) Myotonia Congenita MH (Malignant Hyperthermia) X-Linked Severe Combined Immunodeficiency (X-SCID) GM1-Gangliosidosis Narcolepsy Muscular Dystrophy (MD) MPS ( Mucopolysaccharidosis type VII) Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM / IMGD) Canine Cyclic Neutropenia (Gray Collie Syndrome) Progressive Retinal Atrophy (cord1- PRA / crd4 PRA) L-2-HGA ( L- 2 - hydroxyglutaric aciduria ) L2HGA von Willebrand disease Type I (vWD I) von Willebrand disease Type III (vWD III) Neuronal Ceroid Lipofuscinosis ( CL / NCL ) Trapped Neutrophil Syndrome ( TNS ) Progressive Retinal Atrophy (crd PRA) PDP 1 Deficiency (Pyruvate Dehydrogenase Phosphatase 1 Deficiency) Factor VII Deficiency Progressive Retinal Atrophy (rcd1 PRA) Progressive Retinal Atrophy (rcd3 PRA) Progressive Retinal Atrophy (rcd1a PRA) Juvenile Brain Disease ( JBD ) / Juvenile Encephalopathy ( Epilepsy ) Microphthalmia ( RBP4 ) French Bulldog DNA bundle (DM + HSF4 + CHG + Cy + CMR + CDDY/CDPA) Leonberger KC DNA bundle (LPN1+LPN2+LEMP+LPPN3) Spanish Water Dog DNA bundle Lethal Acrodematitis ( LAD ) MDR1 Gene Varian / Ivermectin Sensitivity * (ABCB1) Exercise Induced Collapse ( EIC ) Dwarfism (Pituitary Dwarfism / Hypopituitarism) Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2) / SOD1 Greyhound Neuropathy (Hereditary Neuropathy) Brittle Bone Disease (Osteogenesis Imperfecta) Glycogen Storage Disease (GSDllla) Hereditary Cataract (HSF4) Neonatal encephalopathy (NE / NEWS) Haemophilia B (factor IX deficiency / F9 ) JEB (Junctional Epidermolysis bullosa) Primary Lens Luxation (PLL) Brachyury (Bobtail Gene / Short Tail / T-Box) Familial Nephropathy (FN) / Hereditary Nephropathy * Startle Disease (SD) / Hyperekplexia Familial Nephropathy (FN) / Hereditary Nephropathy Myostatin Mutation ("Bully" Whippet)/ Double Muscling Hereditary Nephritis / Samoyed Hereditary Glomerulopathy Episodic Falling in Cavalier King Charles Spaniel (EF) Dry Eye and Curly Coat syndrome (CCS) Haemophilia A (factor VIII deficiency / F8) Congenital Hypothyreosis / hypothyroidism ( CHG ) Hereditary Nasal Parakeratosis (HNPK) Juvenile Epilepsy (JE) Musladin-Lueke syndrome (MLS) Ichthyosis ( ICH ) * Neonatal Cortical Cerebellar Abiotrophy (NCCD) Dwarfism (Skeletal Dysplasia 2 / SD2 ) Primary Open Angle Glaucoma (POAG) Progressive Retinal Atrophy (generalized PRA) Progressive Retinal Atrophy (GR-PRA1) Progressive retinal atrophy ( rcd4-PRA) / LOPRA Alaskan Malamute Polyneuropathy (AMPN / IPAM / HPAM) Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) Polycystic Kidney Disease (PKD) Pompe's Disease (Glycogen Storage Disease type II / GSDII) Primary ciliary dyskinesia (PCD) Protein Losing Nephropathy (PLN) Late Onset Ataxia (LOA) Cobalamin Malabsorption (Imerslund-Gräsbeck syndrome (IGS)) Spinocerebellar ataxia (SCA) pap-PRA1 (Progressive Retinal Atrophy) Progressive Retinal Atrophy (BAS PRA) CMSD (Canine Multiple System Degeneration) Hereditary Cataract (HSF4) * Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127) Thrombopathia (Thrombopathy) Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet) Degenerative Myelopathy / degenerative radiculomyelopathy) DM (Exon 1) Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS) Hypomyelination (Shaking Puppy Syndrome) SPS JRT and PRT Pack A: LOA + SCA + JBD JRT and PRT Pack B: LOA + SCA + PLL + JBD + DM2 Leonberger Polyneuropathy 1 ( LPN1) Hereditary Ataxia (HA) Finnish Hound Ataxia / Cerebellar Ataxia (FHA / CAFH) Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH) Persistent Müllerian duct syndrome (PMDS) Fanconi Syndrome (FS) Lagotto Storage Disease (LSD) Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) Progressive Retinal Atrophy (CNGA1 PRA) Achromatopsia (day blindness) / ACHM Progressive Retinal Atrophy (GR-PRA2) Postoperative Hemorrhage (P2Y12 / P2RY12)

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