1 ) Episodic Falling in Cavalier King Charles Spaniel (EF)
Breeds
Cavalier King Charles Spaniel
,
Cavapoo
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Episodic Falling is a genetic neurological disorder found in Cavalier King Charles Spaniels. Episodes are usually triggered by exercise, stress or excitement and are characterised by increased muscle tone and stiffness throughout the thoracic and pelvic limbs resulting in a characteristic 'deer-stalking' position and or collapse. The onset of symptoms is usually between fourteen weeks and four years of age but may appear at any age. Clinical symptoms vary in severity ranging from mild, occasional falling to freezing or seizure-like episodes lasting hours. Severity of the episodes can increase or decrease as the dog gets older. There is no standard pattern to the attacks.
The disease is also known as Exercise-Induced Paroxysmal Hypertonicity, Falling Cavaliers and Collapsing Cavalier Syndrome.
Prof. Dr. Robert Harvey of the London School of Pharmacy has recently identified the underlying genetic defect causing Episodic Falling in Cavalier King Charles Spaniels. LABOKLIN have recently implemented the genetic test for this disease under licence from the London School of Pharmacy. This test is currently patented within Europe, with Laboklin as the testing laboratory.
Description
We also have a special offer:
Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT)
FOR BOTH TESTS.
It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
We will run this test 2 independant times on your sample to ensure that the result is 100% accurate
2 ) Dry Eye and Curly Coat syndrome (CCS)
Breeds
Cavalier King Charles Spaniel
,
Cavapoo
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Affected dog puppies suffer from keratoconjunctivitis sicca from eyelid opening, abnormal (rough/curly) coat and are usually smaller than littermates. Footpads are hyper keratinised from young adulthood including nail growth abnormalities and intermittent sloughing, pain and lameness.
Description
We also have a special offer:
Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT)
FOR BOTH TESTS.
Medium chain acyl-CoA dehydrogenase deficiency (MCADD), a fatty acid oxidation disorder, is an inherited disease affecting the CKCS breed. This condition prevents the normal use of fat as an alternative source of energy during times of fasting or increased metabolic demands. Affected animals cannot burn fat for energy when their bodies run out of glucose, and as a result they may be affected by low blood sugar, altered central nervous system function, coma, or sudden death. With an early diagnosis, MCADD can be managed successfully by diet.
In a recent study, affected dogs showed complex focal seizures with prolonged lethargy, lower responsiveness and proprioceptive ataxia. These conditions occurred several times a week and lasted from 20 minutes up to 24 hours. Urine and blood analysis showed an elevated level of medium chain fatty acids. The symptoms improved under medical treatment and diet change towards low fat diet leading to several month without major seizures. The allele frequency within the CKCS population tested in the publication was 23.5%, which means that 5.52% of the tested CKCS were affected.
Cavalier King Charles Spaniel
,
Dachshund
,
Miniature Wire haired Dachshund
,
Miniature Long Haired Dachshund
,
Miniature Smooth Haired Dachshund
,
Standard Long Haired Dachshund
,
Standard Smooth Haired Dachshund
,
Standard Wirehaired Dachshund
.
The Disease
Myxomatous mitral valve disease (MMVD) is also known as mitral regurgitation, degenerative mitral valve disease and endocardiosis.
Myxomatous mitral valve disease (MMVD) is considered the most common congenital heart disease in dogs as it accounts for more than 70% of all canine heart disease. The disease is chronic and progressive, early symptoms is usually a heart murmur, developing after the age of six. Approximately 30% of dogs with MMVD progress to mitral regurgitation (MR) and eventually heart failure.
The disease is common in small breeds and the incidence is particularly high in some breeds such as the Cavalier King Charles spaniel (CKCS).
The heart has 4 chambers, 2 upper chambers (atria) and 2 lower chambers (ventricles). Blood passes through a valve before leaving each chamber of the heart. The valves prevent the backward flow of blood (regurgitation). The valve between the left atrium and left ventricle is called the mitral valve. The mitral valve is responsible for making sure that blood flows from your left atrium to your left ventricle. It also ensures that blood doesn't flow backward between those two chambers.
Dogs with MMVD have progressive mitral valve degeneration. over time, the abnormal valve allows blood to leak backward, or regurgitate, into the left atrium. As the left atrium becomes bigger and bigger to accommodate the extra blood from the regurgitation, increased pressure develops in the left atrium. The blood returning from the lungs into the left atrium is backed up, causing fluid to build up in the lungs. This is called congestive heart failure. Congestive heart failure can lead to difficulty breathing but can be managed with diuretic medications for a certain period of time.
Trait of Inheritance
Autosomal Recessive mode of inheritance and so a dog must inherit two copies of MMVD, one from each parent to be at high risk of developing the disease
It is very unlikely that the dog will develop Myxomatous mitral valve disease (MMVD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Myxomatous mitral valve disease (MMVD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
American Cocker Spaniel
,
Bichon Frise
,
Boxer
,
Cavalier King Charles Spaniel
,
Cavapoo
,
Chihuahua
,
Cocker Spaniel
,
Dwarf poodle
,
English Cocker Spaniel
,
Havanese - Bichon Havanese
,
Jack Russell Terrier
,
Labrador Retriever
,
Maltese
,
Miniature Poodle
,
Parson Russell Terrier (PRT)
,
Poodle
,
Shih Tzu
,
Standard Poodle
,
Toy Poodle
.
Description
Macrothrombocytopenia ( MTC ) is inherited as an autosomal dominant trait characterized by low platelet count and the presence of some larger than normal platelets in circulation.
Unlike acquired macrothrombocytopenia (thrombocytopenias secondary to infectious agents, medications, immune-mediated causes), this form does not respond to treatment.
It is important to note that these dogs may mistakenly be considered to have an underlying disease that results in thrombocytopenia, such as immune-mediated thrombocytopenia, tick-borne infection, or a bone marrow disorder.
TC ) is inherited as an autosomal dominant trait and results can be Clear (N/N), Affected heterozygous (N / MTC), Affected homozygous (MTC / MTC)
Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form
<Request sample collection
materials> or email: info@laboklin.co.uk.
