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new tests:
new
Kennel Club
DNA testing schemes with LABOKLIN:
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Progressive Retinal Atrophy ( crd3-PRA )
Test number: 8691
Gene Name: crd3-PRA
Short Name: crd3-PRA
Price: £ 48.00 (including VAT)
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Breed
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Glen Of Imaal Terrier ( GIT )
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Glen Of Imaal Terrier ( GIT ).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Progressive Retinal Atrophy ( crd3-PRA ) is a PRA form that has been found in Glen of Imaal Terrier, it is known to be caused by a variant of the ADAM9 gene which is found to be associated with cone-rod dystrophia (crd3). The retinal function of very young affected dogs remains normal but at the age of 12-24 months, the con and later also the rod photoreceptor cells begin to degenerate. Difficulties avoiding obstacles in dimlight are typical first signs of this disease. The degeneration of the photoreceptors progresses and results in complete blindness after several years. At ophthalmoscopic examinations, Clinical effects of crd3 are usually not evident until about 2-2.5 years of age, however, in some cases this may be delayed for several years.
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Trait of Inheritance |
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Trait of inheritance is autosomal recessive which means that the dog must inherit two copies of the mutation in order to develop the disease.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy ( crd3-PRA ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / crd3-PRA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy ( crd3-PRA ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: crd3-PRA / crd3-PRA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Progressive Retinal Atrophy ( crd3-PRA ) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| See also: |
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