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Copper Toxicosis COMMD1 / CT (Copper Storage Disease )
Test number: 8735
Gene: COMMD1
Price: £ 48.00 (including VAT)
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Update Sep 2021 |
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This test is for the Copper Toxicosis causative mutation in the COMMD1 gene.
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Breed
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Bedlington Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Bedlington Terrier.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
Copper toxicosis in Bedlington Terriers is an inherited disorder that results in liver disease from copper accumulation and toxicity. Until recently, dogs have been diagnosed by liver biopsy and quantitative measurement of copper in the liver at or after one year of age. Dogs with copper toxicosis have a normal intestinal absorption of copper and they clear copper from the portal circulation into the liver like healthy dogs. The metabolic defect lies in the excretion of copper from the hepatocytes through the canalicular membrane into the bile canaliculi. Non-excreted copper accumulates and is stored in the lysosomes of the liver cells. Without treatment, affected dogs develop liver disease and die, usually between 3 to 7 years of age.
Another mutation has been found in Labrador Retriever and Doberman and a DNA test is available. The test in Labrador and Doberman is a partner lab test. |
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Description |
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COMMD1 causative muation test
For molecular diagnosis of copper toxicosis in Bedlingtons we are pleased to offer a DNA test for the COMMD1 causative mutation, which replaces our old marker test. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
If a particularly valuable dog turns out to be a carrier, it can be bred to a non-affected animal, and non-carrier puppies can be saved for the next round of breeding.
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Trait of Inheritance |
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Copper toxicosis in Bedlington Terriers is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Copper Toxicosis COMMD1 / CT (Copper Storage Disease ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / COMMD1 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Copper Toxicosis COMMD1 / CT (Copper Storage Disease ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: COMMD1 / COMMD1 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Copper Toxicosis COMMD1 / CT (Copper Storage Disease ) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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