LABOKLIN (UK)| Genetic Diseases | Cats| Skeletal Dysplasia

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Skeletal Dysplasia Test number: 8808 Gene: SD Price: £ 48.00 (including VAT)

Breeds

British Shorthair (BSH) , Scottish Fold Longhair , Scottish Fold Shorthair .

The Disease

In the breed British Shorthair, a mutation in the gene LTBP3 was found to cause skeletal dysplasia. First symptoms like hind limb paraparesis were already shown at the age of 8 weeks in affected kittens. Further symptoms like lordosis and scoliosis, myelopathy and reduced motility of the intestine were shown at the age of 10 weeks. A deformation of the vertebral column was seen in radiological examination. Affected kittens showed deteriorating paraparesis, deformation of multiple thoracic vertebral bodies, stenosis of the vertebral canal, compression of the spinal cord tissue and coprostasis. Due to the severity of symptoms, the affected kittens were euthanized.

Trait of Inheritance

Autosomal recessive mode of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Skeletal Dysplasia. The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / SD [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Skeletal Dysplasia but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: SD / SD [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Skeletal Dysplasia and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

Dam

Offspring