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Cerebellar Ataxia (CA1)
Test number: 8860
Gene Name: CA1
Short Name: CA1
Price: £ 48.00 (including VAT)
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Breeds
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Belgian Shepherd Dog (Groenendael)
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Belgian Shepherd Dog (Laekenois )
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Belgian Shepherd Dog (Malinois)
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Belgian Shepherd Dog
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Belgian Shepherd Dog (Tervuren)
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Pyrenean Mountain Dog (Great Pyrenees)
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The Disease |
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Cerebellar Ataxia (CA1)
Cerebellar Ataxia (CA1) is caused by an autosomal recessive variant in the RALGAPA1 gene, which has been identified in the Belgian Shepherd breeds.
Affected puppies develop cerebellar dysfunction and are less active and alert compared to healthy littermates. The puppies show a wide-based stance and ataxic gait, exaggerated gait movements as well as stumbling, staggering and intention tremor of the head. Mild proprioceptive deficits can also be detected and the occulovestibular response seems to be normal to reduced. Clinical examinations of cerebrospinal fluid and blood remain unremarkable.
CA1 has an early onset of around 4 weeks of age, when the activity and mobility of the puppies increases. In some cases, the cerebellar symptoms were slowly progressive, requiring the puppies to be euthanized due to the severity of the symptoms at the age of 5 weeks. In other cases, the clinical signs were stable until the age of 11 week and the dogs reached adulthood without obvious worsening of the symptoms. |
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Trait of Inheritance |
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Autosomal recessive mode of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Cerebellar Ataxia (CA1). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CA1 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Cerebellar Ataxia (CA1) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CA1 / CA1 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Cerebellar Ataxia (CA1) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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