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Limb Girdle Muscular Dystrophy (LGMD)
Test number: 8863
Gene: SGCA
Price: £ 48.00 (including VAT)
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Breeds
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Dachshund
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Miniature Wire haired Dachshund
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Miniature Long Haired Dachshund
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Miniature Smooth Haired Dachshund
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Standard Long Haired Dachshund
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Standard Smooth Haired Dachshund
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Standard Wirehaired Dachshund
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The Disease |
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Limb Girdle Muscular Dystrophy (LGMD)
Limb Girdle Muscular Dystrophy (LGMD) is an inherited neuro-muscular disease affecting Dachshunds. Affected dogs show clinical signs including exercise intolerance, stiff gait, progressive weakness, the presence of an excess amount of myoglobin in the urine (myoglobinuria) which is due to muscle breakdown releasing a high amount of myoglobin in the blood, as well as difficulty in swallowing food (dysphagia) and aspiration pneumonia.
Markedly and persistently elevated serum creatine kinase (CK) activities can be measured in blood examinations. The symptoms appeared in young adult animals, approximately starting at the age of 7-17 months.
A mutation in the sarcoglycan alpha subunit (SGCA) gene has been identified as associated with Limb-Girdle Muscular Dystrophy (LGMD) in the Dachshund breed. |
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Trait of Inheritance |
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autosomal recessive trait of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Limb Girdle Muscular Dystrophy (LGMD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / SGCA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Limb Girdle Muscular Dystrophy (LGMD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SGCA / SGCA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Limb Girdle Muscular Dystrophy (LGMD) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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