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1 ) Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH)
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Breeds
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Akita
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American Akita
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Italian Greyhound
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Parson Russell Terrier (PRT)
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Samoyed
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Akita.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH) is an inherited genetic disorder affecting the tooth enamel that occurs in Italian Greyhounds. Affected dogs are unable to develop normal tooth enamel (Emnamel Hypoplasia) resulting in teeth being misshaped with roughening / thinning surface and greyish or brownish spots.
The disease affect both baby and permanent teeth. In affected dogs, permanent teeth are pointed and unusually small with gaps between the teeth due to increased enamel wear. The gaps between the teeth increase as the dog gets older.
There is no relation between the disease and either autoimmunity or periodontal disease.
In a recent study conducted on Italian Greyhounds from populations in the US and Canada, it is estimated that about 14% are affected and 30% are carriers. We do not yet have reliable information on the prevalence of the mutation in the UK. |
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / FEH [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: FEH / FEH [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH) and will pass the mutant gene to its entire offspring
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2 ) Hereditary Nephritis / Samoyed Hereditary Glomerulopathy
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Samoyed.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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Description |
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Hereditary nephritis / glomerulonephropathy in Samoyed is a recessive, X-linked hereditary disease that affects young male dogs more severely than females. Affected males and females spontaneously develop proteinuria, but only males progress to renal failure. Affected male puppies usually show symptoms of the disease by 2 to 3 months of age. They start to lose weight noticeably and kidney function deteriorates rapidly, resulting in death by an early age (approximately 1 year). Females who carry the disease also lose weight and develop proteinuria between two and three months of age, but the disease is less severe and does not progresses to kidney failure.
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Trait of Inheritance |
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X-Chromosomal Dominant with Variable Penetrance
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: HN [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / HN [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: HN / HN [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring
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3 ) XL - PRA (Progressive retinal Atrophy)
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Breeds
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Samoyed
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Siberian Husky
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Samoyed.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Normally, the vision receptors in the eyes undergo a continual process of replacement and renewal. But with PRA this process slows and, one day, stops. The night vision receptors are the first to fail, and then, a while later, day vision starts to degenerate.
XL-PRA is a "late-onset" form of PRA. It usually isn't until dogs are three to five years old that the first clinical signs of disease start to manifest
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Description |
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Normally, the vision receptors in the eyes undergo a continual process of replacement and renewal. But with PRA this process slows and, one day, stops. The night vision receptors are the first to fail, and then, a while later, day vision starts to degenerate.
XL-PRA is a "late-onset" form of PRA. It usually isn't until dogs are three to five years old that the first clinical signs of disease start to manifest
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Trait of Inheritance |
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: XL - PRA [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop XL - PRA (Progressive retinal Atrophy) and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / XL - PRA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: XL - PRA / XL - PRA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop XL - PRA (Progressive retinal Atrophy) and will pass the mutant gene to its entire female offspring
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Price
for the above 3 tests
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£ 132.00 (including VAT)
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