Polioencephalopathy (PE) in Eurasier
A genetic form of polioencephalopathy has been identified in Eurasier dogs, linked to a variant in the MECR gene. Affected puppies typically begin showing signs between 2 and 6 months of age. These include movement episodes such as wobbly walking (ataxia), exaggerated leg movements (hypermetric gait), muscle spasms (dystonia), and sudden flexing or stretching of the front legs. These episodes often become more frequent and severe over time, and may be triggered by excitement, loud noises, or overstimulation. No changes in behaviour or awareness have been reported.
Common symptoms observed in affected Eurasier puppies include:
- Generalized ataxia (wobbly walking)
- Hypermetric gait (exaggerated limb movements)
- Dystonia (muscle spasms)
- Uncontrolled flexion and extension of the forelimbs
- Progressive difficulty walking and standing
- Muscle atrophy
- Abnormal posture
- Divergent strabismus (eyes pointing outward)
Polioencephalopathy is a neurological disorder involving changes in the brain’s grey matter. It can be caused by metabolic issues and is difficult to diagnose based on symptoms alone, as signs can vary widely.
The MECR gene encodes an enzyme essential for mitochondrial energy metabolism. Variants in this gene can lead to neurodegenerative changes, especially in energy-demanding tissues such as the basal ganglia and the optic nerve.
This DNA test helps identify carriers and affected dogs early, allowing breeders to make informed decisions and reduce the risk of producing affected puppies.
Trait of Inheritance: Autosomal recessive
