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Dalmatian DNA bundle (ARDS, DD, HUU, LSD, B-Locus, E-Locus)
Test number: 8966
Short Name: Dalmatian DNA bundle (ARDS, DD, HUU, LSD, B-Locus, E-Locus)
Price: £ 138.00 (including VAT) for all 6 tests
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1 ) Acute Respiratory Distress Syndrome ( ARDS )
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The Disease |
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Acute Respiratory Distress Syndrome (ARDS) is an inherited fatal respiratory disease affecting the Dalmatian breed characterised by impaired pulmonary gas exchange, which leads to inflammation and carries substantial risk of death.
The main clinical signs include progressive abnormally rapid breathing (tachypnea) and breathing difficulty (dyspnea) leading to a severe respiratory distress and euthanasia.
Prevalence: it is estimated that 1.7 % of Dalmatians are carriers) |
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2 ) Dwarfism ( Disproportionate Dwarfism ) DD
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Breeds
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Dalmatian
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Dogo Argentino
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Hungarian Vizsla (Magyar Vizsla / Smooth haired)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Dalmatian.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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A genetic variant of the PRKG2 gene has been identified to be associated with disproportionate dwarfism in the Dogo Argentino breed. The disease becomes apparent at the age of about 2 months. Affected dogs have a shorter height and body length. A disproportionally large head with a pronounced vertical groove between the eyes and forelimb angular aberrations (carpus valgus) that can cause gait abnormalities are also typical symptoms of the disease.
The PRKG2 gene encodes for a protein which has a signalling role in the termination of chondrocyte proliferation and initiation of the differentiation into bone. |
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Dwarfism ( Disproportionate Dwarfism ) DD. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / DD [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Dwarfism ( Disproportionate Dwarfism ) DD but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: DD / DD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Dwarfism ( Disproportionate Dwarfism ) DD and will pass the mutant gene to its entire offspring
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3 ) Hyperuricosuria / Urate Stones (HUU, SLC)
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New Kennel Club DNA testing scheme for HUU in Dalmatian |
The Kennel Club has agreed a new DNA testing scheme for Hyperuricosuria (HUU) / Urate Stone Disorder (USD) in Dalmatian. Under this scheme, HUU test results can be sent by Laboklin to the Kennel Club to be recorded and published only if the submission and testing procedure complies with the following protocol:
- that dogs to be tested are microchipped and registered before the test sample is taken;
- that the test sample (whether buccal swab or EDTA blood sample or other) is taken by a veterinary surgeon or veterinary nurse who first confirms the microchip identity of the test subject and records both the microchip number and registration name on the sample container/package;
- that the sample is sent directly by the veterinary surgery to LABOKLIN.
Copies of all future test certificate results issued by LABOKLIN will only be recorded by the Kennel Club at this time provided they comply with the above protocols.
Please ensure that the veterinary surgeon or veterinary nurse taking the sample complete the vet section on the order form, sign it and stamp it, send it directly to Laboklin and ensure that there stamp is on the package / envelope containing the samples submitted. |
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Breeds
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All Dog Breeds
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Russian Black Terrier ( RBT )
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Bulldog (English)
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Dalmatian
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Giant Schnauzer
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Hungarian Vizsla (Magyar Vizsla / Smooth haired)
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Large Munsterlander
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Spanish Water Dog
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Weimaraner
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Hungarian Wirehaired Vizsla (Vizslak)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Russian Black Terrier ( RBT ), Bulldog (English), Dalmatian, Giant Schnauzer, Large Munsterlander, and Hungarian Wirehaired Vizsla (Vizslak).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
Hyperuricosuria is characterized by elevated levels of uric acid in the urine. This disease predisposes dogs to form stones in their bladders or sometimes kidneys. The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier. The mutation was recently described in Spanish Waterdog (https://www.ncbi.nlm.nih.gov/pubmed/26538670). Here at Laboklin we recently tested an Australian Shepherd as carrier of HUU but we have no information about its prevalence in this breed, and therefore testing recomended if your aussie is showing symptoms of the disease. |
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Trait of Inheritance |
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Hyperuricosuria is inherited as a simple autosomal recessive trait.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Hyperuricosuria / Urate Stones (HUU, SLC). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / HUU [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Hyperuricosuria / Urate Stones (HUU, SLC) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: HUU / HUU [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Hyperuricosuria / Urate Stones (HUU, SLC) and will pass the mutant gene to its entire offspring
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4 ) Lysosomal Storage Diseases (LSD)
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Breeds
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Dalmatian
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Doberman Pinscher
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Weimaraner
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The Disease |
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Lysosomal Storage Diseases (LSD)
Lysosomal storage diseases refer to a collection of disorders characterized by the body's inability to produce essential metabolic enzymes. Lysosomes serve as cellular ‘recycling centres’ converting worn-out materials into substances that cells can utilize. When specific metabolic enzymes are lacking, the unprocessed material accumulates, leading to tissue damage and eventual failure of organ systems.
Symptoms include decreased vision, changes in behaviour, ataxia, incoordination, lethargy, weakness, tremors, seizures, stiff gait and dementia.
Please note that the variant which cause the disease in Dalmatian is different from the variant which causes it in Doberman and so the test is also different. We will run the test that is relevant to the breed. If the breed isn’t listed, please specify which variant(s) you would like us to perform. Each variant will be charged separatedly.
additional information
In Dalmatian, a genetic variant in the CNP gene is responsible for lysosomal storage disease. Affected dogs exhibit gradually worsening symptoms such as abnormal behavior, cognitive decline, loss of coordination, apparent visual impairment, anxiety, pacing and circling, hypersensitivity, sleep disturbances, and loss of control over urination and defecation. These symptoms typically begin to appear around 18 months of age.
In Doberman dogs, a genetic variant in the MAN2B1 gene causes lysosomal storage disease. Symptoms in affected dogs can be observed as early as 2 months old, including clumsiness, difficulty standing, and frequent falls. Neurological examinations reveal slightly reduced mental alertness, proprioceptive ataxia, asymmetric reduced menace response, and moderate divergent strabismus.
Note: different variant affects each breed |
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5 ) Coat Colour: B Locus (bd, bc, bs) Brown Coat Colour
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Breeds
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All Dog Breeds
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American Cocker Spaniel
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Australian Shepherd
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Bedlington Terrier
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Border Collie
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Welsh Corgi (Cardigan)
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Dachshund
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Dalmatian
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Doberman Pinscher
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English Cocker Spaniel
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Flatcoated Retriever
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Fox Terrier
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French Bull Dog
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Galgo Espanol
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German Longhaired Pointer
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German Shorthair Pointer
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Gordon Setter
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Griffon Bruxellois
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Irish Soft Coated Wheaten Terrier
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Koolie ( Australian Koolie )
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Labrador Retriever
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Miniature Pinscher
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Newfoundland
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Pointer
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Portuguese Waterdog
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Scottish Terrier
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Weimaraner
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Description |
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This test is for the 'bd', 'bc' and 'bs'variants, which are described in all dog breeds and are responsible for the brown coat colour, which is also known in some breeds as liver, chocolate, chestnut, sedge, and less frequently, red. Two copies of the b-allele are needed to dilute black pigment to brown. For red or yellow dogs, the brown allele does not dilute the hair colour, but will change the colour of nose and foot pads from black to brown if two brown alleles are present.
When one of the variants is found homozygous (bd/bd, bc/bc or bs/bs), dark pigment (eumelanin) is diluted to brown in the pigmented areas. However, when several variants of the B-locus are found in heterozygous state (example N/bd and N/bc), it is not always possible to directly determine the influence on the eumelanin because this depends on whether the variants are located on the same or different chromosmes, however, the dog will definitely pass the variants to its offspring.
Australian Shepherd and Lancashire Heeler Please note there are two additional rare variants, which are not analysed in this test. The 'b4' variant which is only found in few Australian Shephered lines, and the 'be' variant which is only found in Lancashire Heeler, and therefore for a complete analysis in Australian Shepherd and Lancashire Heeler, you need to order this test in addition to the rare variant test . You can take advantage of our special offer 'second coat colour test at half price (excluding bundles)'.
French Bulldog
In French Bulldog, in addition to the B-locus, the Cocoa gene is also responsible for the brown coat colour, and therefore, in addition to this test you also need to order the Cocoa coat colour test . You can of course take advantage of our special offer 'second coat colour test at half price (excluding bundles)'.
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6 ) Coat Colour: E-Locus E1 (yellow, lemon, red, cream and appricot)
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Breeds
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Afghan Hound
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All Dog Breeds
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Australian Cattle Dog
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Australian Shepherd
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Beagle
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Border Collie
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Brittany ( Brittany Spaniel )
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Welsh Corgi (Cardigan)
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Chinese Chow Chow
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Cocker Spaniel
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Dachshund
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Dalmatian
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Doberman Pinscher
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English Cocker Spaniel
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English Setter
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English Springer Spaniel
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Field Spaniel
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Flatcoated Retriever
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Foxhound
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French Bull Dog
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German Longhaired Pointer
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German Shepherd
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German Wirehaired Pointer
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Gordon Setter
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Koolie ( Australian Koolie )
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Labrador Retriever
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Lowchen
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Miniature Schnauzer
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Pointer
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Pomeranian
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Poodle
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Pudelpointer
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Description |
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Coat Colours
As with other mammals, dogs have two major types of pigment in their coat: dark pigment (Eumelanin) which is responsible for black and brown in the pigmented areas, and yellow pigment (Phaeomelanin) which is responsible for red, yellow, orange, golden, cream, apricot in the pigmented areas. The colour varieties seen in dogs are due to genes controlling the amount, extent, and distribution of these two colour pigments.
E-Locus
The E-Locus has a number variants, the 'e1' variant which is responsible for the yellow colours in most breeds, the rare 'e' variants which are repsonsible for the same but in certain breeds, and the special variants 'eA', 'eg' and 'eh' which are responsible for specific colours, some of them occurs only in specific breeds including domino, grizzle, sable and hare-pied. The EM variant is also located at the E-Locus and esponsible for the melanistic mask. This test is only for 'e1' variant.
The 'e1' variant
This test detects the 'e1' variant of the E-Locus, the 'e1' variant is responsible for the red, yellow, orange, golden, cream, apricot coat in the pigmented area in most breeds. The 'e1' variant is recessive which means that two copies of 'e1' (e1/e1) are needed for the dog to be red, yellow, orange, golden, cream, apricot in the pigmented areas. This test number 8018 which is offered in this test as an individual test, however, it is also included in our popular Laboklin Coat Colour Bundle (bundle number 8654)
Australian Cattle Dog
Please note there are additional rare E-Locus variants, which are not analysed in this test. The 'e2' variant is found in Australian Cattle Dog only and therefore for a complete analysis in Australian Cattle Dog, you need to order this test 'e1' in addition to the rare variant test . You can take advantage of our special offer additional coat colour test at half price'.
E-Locus Special colours: 'eA', 'eG' and 'eH'
Testing for these special colours is avaialable in a separate test, for more information check test number 8682 special E-Locus variants 'eA', 'eG' and 'eH'. You can take advantage of our special offer additional coat colour test at half price'.
EM-Locus Melanistic Mask
Testing for Melanistic Mask is available in a separate test, for more information check test number 8146 EM-Locus (Melanistic Mask). You can take advantage of our special offer additional coat colour test at half price'.
Order of dominance: EM> EG> E> EH> e.
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Price
for the above 6 tests
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£ 138.00 (including VAT)
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