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Primary Hyperparathyroidism (PHPT)
Test number: 8976
Short Name: PHPT
Price: £ 48.00 (including VAT)
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Breeds
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German Spitz (Mittel)
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Keeshond
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Keeshond.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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Description |
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Primary Hyperparathyroidism (PHPT) in Keeshond & German Spitz
Primary hyperparathyroidism (PHPT) is an inherited disorder of the parathyroid glands. It occurs when abnormal parathyroid cells secrete parathyroid hormone (PTH) inappropriately. This leads to persistently high calcium levels in the blood (hypercalcemia), which can cause serious health problems over time. PHPT is particularly recognized in Keeshond dogs, with German Spitz also predisposed.
Symptoms
- Excessive thirst and urination
- Weakness or lethargy
- Loss of appetite
- Vomiting
- Weight loss
- Kidney or urinary tract complications
- In severe cases, life-threatening hypercalcemia
The Test
This genetic test identifies the variant associated with PHPT in Keeshond and German Spitz breeds. The disorder is inherited in an autosomal dominant fashion, meaning only one copy of the variant is sufficient to increase risk. The condition shows high age-related penetrance, with most affected dogs developing signs later in life, typically after 8 years of age.
Inheritance
- Autosomal dominant inheritance: Dogs with one copy of the variant are at risk of disease
- High penetrance: Most affected dogs will eventually develop PHPT, usually later in life
- Breeding impact: Identifying affected dogs helps breeders avoid passing the variant to offspring
- Health impact: Early detection allows vets and owners to monitor calcium levels and manage the condition before complications arise
FAQ
- What is PHPT? A genetic disorder where the parathyroid glands produce too much hormone, leading to high calcium levels
- What are the symptoms? Excessive thirst and urination, weakness, loss of appetite, vomiting, weight loss, kidney issues. Signs usually appear later in life, often after 8 years
- How is PHPT inherited? Autosomal dominant. A dog only needs one copy of the variant to be at risk
- What does 'dominant' mean for breeding? Dogs with the variant are themselves at risk. If a dog has the variant, it is likely to develop PHPT
- What does 'age-related penetrance' mean? Most dogs with the variant will eventually show signs, but usually later in life. Early testing is important
- Why should breeders test? To identify affected dogs before symptoms appear, avoid passing the variant to offspring, and protect the long-term health of the breed
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Price
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£ 48.00 (including VAT)
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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